Is there a direct subway from Guangzhou East to Dongguan West?

No, according to Baidu map, from Guangzhou east to Dongguan west, you need to take the north extension of Metro Line 3 → Metro Line 3 → Metro Line 5 → Metro 13 → Road 378 →6 13, and there is no direct access to the urban rail. Convenient subway also makes residents in Huizhou and Dongguan exchange visits more and more frequently, which greatly facilitates the lives of residents in the two places.