Quick notes on drug test points for practicing pharmacists: anti-malignant tumor drugs

Introduction: The first examination subjects for practicing pharmacists mainly test the professional knowledge necessary for engaging in drug quality supervision and pharmaceutical services. Among them, the anti-malignant tumor drug test points require the ability to memorize, understand, analyze and apply. , in order for all the candidates preparing for the exam to review and prepare more efficiently and with high quality, let’s take a look at the shorthand of the first test point for practicing pharmacists with the editor: anti-malignant tumor drugs.

1. Drugs that affect nucleic acid biosynthesis: also known as antimetabolites.

5-Fluorouracil: Oral absorption is irregular, usually intravenous infusion and intravenous injection. Competing to inhibit thymidylate synthase. Mainly acts on cells in S phase. Essential medicine for the treatment of gastrointestinal tumors and breast cancer. Severe irritation, liver damage, and jaundice.

Methotrexate (MTX): A drug that inhibits dihydrofolate reductase. It is well absorbed orally and selectively acts on the DNA synthesis stage. For acute leukemia and chorioepithelial carcinoma in children.

Arabinothymidine: destroyed by oral administration. Intravenous injection. Treatment of acute myeloid or monocytic leukemia in adults.

Hydroxyurea: well absorbed orally, used for chronic myelogenous leukemia.

2. Drugs that directly damage DNA and prevent its replication: alkylating agents.

Nitrogen mustard hydrochloride: low selectivity, strong local irritation, can only be injected intravenously.

Cyclophosphamide: It is well absorbed orally and is a cycle-non-specific drug. It has significant effect on malignant lymphoma. Immunosuppression is often used to treat autoimmune diseases. During medication, add sufficient fluid or sodium ethyl sulfonate to reduce toxicity.

Mitomycin

Bleomycin: used for squamous cell carcinoma.

Combined with cisplatin and vinblastine to treat testicular cancer. Pulmonary fibrosis, fever, hair loss.

Cisplatin (DDP): Ineffective when taken orally, with broad anti-tumor spectrum.

3. Drugs embedded in DNA that interfere with the transcription process: actinomycin (dactinomycin).

Daunorubicin: administered intravenously, used to treat acute lymphoblastic leukemia or acute myelogenous leukemia. Cardiotoxicity.

Adriamycin: intravenously administered, adverse reactions include bone marrow suppression and stomatitis.

4. Drugs that interfere with mitosis and affect protein synthesis.

Vincristine: can cause cells to undergo mitosis in metaphase. It is the drug of choice for inducing remission in acute lymphoblastic leukemia. It has good efficacy and rapid onset of action, and can be used as an induction reliever in combination with prednisone.

Adverse reactions: Mainly neurological symptoms, numbness of fingers and toes, peripheral neuritis.

The above is the relevant content that the editor has compiled and shared with you today about "Quick Notes on the Examination Points for Licensed Pharmacists: Anti-Malignant Tumor Drugs". I hope it will be helpful to you who are preparing for the exam. At the same time, it is worth noting that the interpretation of relevant national policies for practicing pharmacists also needs to be paid attention to, so as not to do useless work. Well, today’s content will be shared here. If you want to know more about the medical qualification examination, preparation, promotion, registration, certification and other related information , welcome to follow the editor for more information. You also have the opportunity to receive free learning materials and free courses~