My wife has lost contact in the United States, what should I do?

First of all, you need to know their approximate location, which state or city.

Then contact the local embassy and the local immigration bureau to find out whether they have come to stay here temporarily or If there is data on settlement, it should be easy to handle.

If there is no data, I think it may not be in that place, and it will be quite slim to find it!]

Hope to adopt