What does it mean that syphilis serum tppA test is positive?

Hello, tppa positive is an antibody produced after syphilis infection. Syphilis, whether cured or not, is positive and cannot turn negative. If it has been treated, don't worry.

Serological detection of syphilis There are many methods for serological detection of syphilis, including non-treponema pallidum antigen (cardiolipin antigen) and treponema pallidum specific antigen. The former includes rapid plasma reagin ring card test (RPR) and toluidine red unheated serological test (TRUST), which can be used as a quantitative test to judge the curative effect and the degree of disease activity. The latter, such as Treponema pallidum particle agglutination test (TPPA) and Treponema pallidum enzyme-linked immunosorbent assay (TP-ELISA), have strong specificity and are used to confirm Treponema pallidum infection.

Detection of IgM antibody of Treponema pallidum: After syphilis infection, IgM antibody first appeared, and with the development of the disease, IgG antibody appeared and rose slowly. After effective treatment, IgM antibody disappeared, while IgG antibody persisted. TP-IgM antibody cannot pass through placenta. If the baby is TP-IgM positive, it means that the baby has been infected. Therefore, the detection of TP-IgM antibody is of great significance to the diagnosis of infant fetal syphilis.