From which century did American immigrants mainly complete their migration?

From the end of 15 to the end of 18, after the opening of the new air route, a large number of European colonists arrived in America, and immigrants slaughtered local indigenous Indians and spread diseases, resulting in a sharp decline in the Indian population. At the same time, mining mineral deposits and building large farms require a lot of labor, and the slave trade is booming. This should be an important stage of American immigration.