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What hard science fiction stand-alone games are there?

Strategical Stars, Endless Space, Interstellar Colonization, Galactic Civilization, A.D. 225, UFO 2 and Civilization

Real-time Strategy empire of the sun's Original Sin: Rebellion, Home 2, Halo: War, StarCraft II and Warhammer 4《X3: Mass Effect series

YoRHa No.2 Type B and generate

There are so many mainstream PCs, as well as Gundam series and Star Wars series.