Can the green card physical examination report be sent to the immigration office by itself? Is it safe?

It's safe to deliver it yourself. According to Netease News, because the hospital is not responsible for submitting the medical report, the applicant needs to send it to the immigration office by express after receiving the report. When confirming the recipient, the new delivery method requires the recipient to show his/her ID card and sign for the delivered documents. Applicants can also fill in PDF documents by standard mail, PS-380 1 form and PS-380 1-A postal system form, and sign agreements with hotels, apartments and other similar institutions to authorize other institutions to sign documents on behalf of the applicants. So it's safe for you to send it to immigration yourself.