The historical negative influence brought by Columbus' discovery of the new continent of America. Be comprehensive.

1. After Columbus discovered America, European immigrants flooded in and occupied the living space of Native Americans (Indians). 2. European colonists, first Spain and Portugal, then Britain and France, occupied Indian land, plundered natural resources and destroyed Indian civilization. European immigrants brought smallpox, measles and other infectious diseases from Europe. Indians living in America for a long time were not immune to these diseases, and Spanish and British colonists slaughtered and persecuted them, resulting in a large number of Indian deaths. By the end of 18, the Indians in Mexico and Cuba were extinct.