What is the relationship between the three ancient civilizations of Macedonia, Greece, and Persia?

Macedonia was a country led by the famous Alexander the Great that arose after the fall of ancient Greece. In fact, it was also derived from Greek soil. Persia is actually today's Iran. At the same time as ancient Greece, it competed for hegemony in the Mediterranean. The famous Greco-Persian War once occurred in Greece, and ancient Greece won. Persia gradually declined in the Mediterranean region.