Doesn't cde rest on weekends?

Rest. According to official website's inquiry, CDE US Food and Drug Administration, that is, the drug evaluation center, is the technical evaluation institution of drug registration of the US Food and Drug Administration, with working hours from Friday to Tuesday and weekends off. CDE mainly provides technical support for drug registration, and is responsible for organizing the technical review of drug registration applications according to the relevant regulations on drug registration management promulgated by the US Food and Drug Administration.