Amikaxing manufacturing enterprise

Livzon Pharmaceutical Group Co., Ltd., Jiangsu Wuzhong Industrial Co., Ltd. Suzhou Sixth Pharmaceutical Factory, Anhui Fengyuan Pharmaceutical Co., Ltd., Shandong Qilu Pharmaceutical Co., Ltd., Guangdong Bangmin Pharmaceutical Co., Ltd., Shanghai Xudonghaipu Pharmaceutical Co., Ltd., Guangdong Nanguo Pharmaceutical Co., Ltd., Sichuan Chuantou Pharmaceutical Co., Ltd., Ningxia Pharmaceutical Factory, Shaanxi Yongshou Pharmaceutical Co., Ltd., Chongqing Daxin Pharmaceutical Co., Ltd., Chengdu No.4 Pharmaceutical Factory, Chengdu Tongde Pharmaceutical Co., Ltd. Deyang Kang Hua Pharmaceutical Co., Ltd., Guangdong Jiangmen Pharmaceutical Factory, Hunan Sichuang Pharmaceutical Hanchuan Pharmaceutical Factory, Fujian Fuqing Pharmaceutical Co., Ltd., Zhejiang Yongning Pharmaceutical Factory, Zhejiang Pharmaceutical Co., Ltd. Xinchang Pharmaceutical Factory, Anhui Lianyi Pharmaceutical Co., Ltd., Zhejiang Tianrui Pharmaceutical Co., Ltd., Zhejiang Cheng Yi Pharmaceutical Co., Ltd., Jiaxing Pharmaceutical Co., Ltd., Jiangsu Su Xing Pharmaceutical Co., Ltd., Dongtai Kangyi Pharmaceutical Co., Ltd., Gaoyou Pharmaceutical Factory, Jiangsu Zhengtian Pharmaceutical Co., Ltd., Suzhou Pharmaceutical Group Co., Ltd

It is absorbed quickly after intramuscular injection. It is mainly distributed in extracellular fluid, and the concentration in cerebrospinal fluid of normal infants can reach 10 ~ 20% of the blood drug concentration in the same period. Meningeal inflammation can reach 50% of the blood drug concentration in the same period, but the concentration in heart, auricle, pericardial fluid, muscle, fat and interstitial fluid is very low. 5 ~ 15% drugs are redistributed to various tissues and can be accumulated in renal cortical cells and inner ear fluid. Through the placenta, the urine concentration is high and the synovial fluid can reach the therapeutic concentration. The concentrations of bronchial secretions, bile and aqueous humor are low, and the concentrations in ascites are difficult to predict. The distribution volume is 0.2 1L/kg, and the protein binding rate is low, which can be combined with tissues in renal cortex. After intramuscular injection, the plasma concentration reached its peak in 0.75 ~ 65438 0.5 hours. After intramuscular injection of 250 mg, 375 mg and 500mg, the average peak concentrations were 12, 16 and 2 1μg/ml, respectively, and the urine concentration at 6 hours was 560, 700 and 830μg/ml, respectively. After intravenous drip 15 ~ 30 minutes, the peak blood concentration reached 500mg each time, and the average peak blood concentration at the end of 30 minutes was 38μg/ml. The blood concentration of patients with fever decreased. T 1/2 is 2 ~ 2.5 hours for adults, 30 hours for anuria patients and 1 ~ 1.5 hours for burn patients. Fetal 3.7 hours, newborn 4 ~ 8 hours (inversely proportional to birth weight and age). This product is not metabolized in the body. It is mainly excreted by glomerular filtration, and 84 ~ 92% is excreted within 9 hours; After intramuscular injection of 0.5g, the urine concentration can be as high as 800μg/ml, 94-98% can be excreted within 24 hours, and it can be completely excreted within 10-20 days. Hemodialysis and peritoneal dialysis can remove a considerable amount of drugs from the blood, thus significantly shortening the half-life.