What does it mean that there are repeated cases of rehabilitation personnel in Sichuan?

This means that everyone must remember one sentence: as long as the epidemic is still happening, we must never take it lightly!

Let's briefly review this relapse case in Chengdu, Sichuan:

It is reported that in the afternoon of February 19, novel coronavirus patients who went home for isolation after being cured in Wangjiang Jinyuan, Chengdu, Sichuan Province, were found to be positive for nucleic acid on the first 10 day after going home for isolation. Relevant institutions have successively taken over their families and patients. After verification with the Sichuan Provincial Health and Health Commission, the information is true. (Source: Beijing News)

This matter also successfully boarded today's hot search, which shows that everyone is very concerned about this matter! Judging from the content, it is indeed a COVID-19 patient who was cured 10 days ago. 10 days later, I went back to check and found that the nucleic acid was positive. Isn't it a surprise?

Everyone is concerned and surprised for a reason! Because in general, there are strict standards for a COVID-19 patient to be discharged from hospital, and the following four items must be met before he can be discharged by our doctor:

First, it is normal to take temperature continuously for more than three days;

Second, respiratory symptoms have improved significantly;

Third, lung imaging showed that acute exudative lesions were significantly improved;

Fourthly, two consecutive respiratory tract samples have negative nucleic acid tests, and the interval between two consecutive tests and sampling should be at least 1 day.

And this COVID-19 patient in Chengdu, Sichuan, must have met the above criteria before leaving the hospital. That is to say, before 10, his respiratory tract sample was negative for nucleic acid.

Then 10 days later, the nucleic acid was positive. What happened?

Didn't you say that under normal circumstances, COVID-19 won't be infected again in a short time after being cured? Didn't you say there would be antibodies? Why didn't antibodies appear, but positive ones appeared?

Of course, it can never be said that people who are cured and discharged from hospital have no antibodies. Because watching the recovered people donate their own plasma, many critically ill patients have been cured, and we know that most people still have virus antibodies after being cured!

At the same time, it cannot be considered that the recovered patient with positive nucleic acid reexamination is reinfected. The cured COVID-19 patients and their families stayed at home for 10 days after returning home, and all materials were delivered to the door by the property, and the way of follow-up visit was also to follow the designated route in the designated hospital. So the possibility of reinfection of this patient can be basically ruled out. Of course, we don't know the specific situation of the patient's family, and the official has not announced it.

However, judging from the current news, I personally think that there are three reasons why the recovered patients are positive after 10, which deserves our attention!

First, it may be related to the "false negative" and "false positive" of nucleic acid detection at present! I told you a long time ago that the nucleic acid detection was inaccurate, and Academician Wang Chen of the Academy of Engineering also said that the positive rate of nucleic acid was between 30% and 50%.

Why not 100%?

Second, it may be related to our current understanding of novel coronavirus. In fact, in the current research on coronavirus, it has been found that coronavirus has the ability to escape our innate immune response, that is, coronavirus may have the ability to escape our immune cells. Of course, whether novel coronavirus exists this time needs further study, because this virus is really too new for us humans, and it needs time to study it clearly.

However, for most viruses in the biological world, there are actually strategies to escape our host immune system in one way or another (as shown in the figure below). For example, some viruses avoid being hunted by infecting cells or tissues that our immune system cannot always reach; Other viruses evade the detection mechanism of our immune system by limiting their genome expression, making it difficult for our immune system to find it, and so on.

In a word, the virus is more complicated and cunning than everyone thought, and this time novel coronavirus is constantly refreshing our understanding of the virus, so it is really necessary to strengthen the research on the virus, especially the coronavirus.

Third, it may be related to the fact that our current treatment of novel coronavirus is not mature enough and there is no specific medicine. Why do you say that? Because although we have so many drugs for treating COVID-19, such as chloroquine phosphate, these drugs can't be said to be specific drugs. They can only help us to limit the replication and reproduction of the virus to a certain extent, but to really kill, especially to remove the virus from the body, we must rely on our own immunity.

It is possible that after a period of treatment by our doctors, some patients have killed most of the viruses, but may only inhibit some of them. This discharge, because everyone's physique is different, there are individual differences or other reasons, resulting in decreased immunity after discharge, there may be a very small number of patients like Chengdu, Sichuan, where the virus appears repeatedly. It's possible.

Therefore, the occurrence of this case is not only a bad thing, but also a wake-up call for us to strictly follow the doctor's advice. The discharged patients should strictly adhere to home isolation rehabilitation 14 days, and their families should also do their own protection and health monitoring, so that the recovered patients can receive follow-up and follow-up as required.

As long as the epidemic continues, we must not take it lightly. Remember this sentence, it must be true!