Discharge standard of pollutants in pharmaceutical industry

The pharmaceutical industry is an important part of the national economy, which has made important contributions to the growth of China's total economic output, but it has also caused serious environmental pollution. It is reported that in order to strengthen the environmental management of pharmaceutical enterprises and reduce the intensity of pollution discharge, the State Environmental Protection Administration is working on formulating pollutant discharge standards for the pharmaceutical industry. A few days ago, the reporter interviewed the relevant person in charge of the Science and Technology Standards Department of the State Environmental Protection Administration (hereinafter referred to as the "person in charge").

Reporter: The state has promulgated the comprehensive discharge standards for sewage and air pollutants. Why?

We also need to set special emission standards for pharmaceutical companies?

Person in charge: The pollutant discharge standard is the basic legal system for controlling pollution sources, the basis for environmental law enforcement and the road sign for the green development of enterprises. The emission standard is a restrictive regulation on harmful substances discharged into the environment and various factors that cause pollution according to the existing best pollution control technology and considering the economic affordability. Its formulation is based on pollution control technology (production process, pollution prevention and control, terminal treatment, etc.). ), and consider environmental risks; The form of expression is mainly digital restriction, but also operational standards and technical management norms. In order to enhance the pertinence and operability of standards, in recent years, our bureau has intensified the formulation of industrial pollutant emission standards, gradually changed from a comprehensive and industrial emission standard system to an industrial emission standard system, improved the coverage of industrial emission standards, and gradually narrowed the scope of application of general pollutant emission standards. According to incomplete statistics, there are more than 5,000 manufacturers of raw materials and pharmaceutical preparations in China, which are characterized by a large number of enterprises, small scale, scattered layout, large input of raw materials in the production process, small output ratio, high added value of products and prominent pollution problems. Therefore, it is necessary to formulate emission standards specifically for pharmaceutical enterprises.

Reporter: What is the progress in the compilation of pollutant discharge standards for the pharmaceutical industry?

Person-in-charge: Since 2003, our bureau has started to formulate pollutant discharge standards for pharmaceutical industry. Firstly, the standard system is studied. Based on the comprehensive analysis of the production process and pollutant emission characteristics of pharmaceutical industry at home and abroad, combined with the characteristics of pharmaceutical industry in China and the needs of environmental management, the pollutant emission standard system of pharmaceutical industry was determined, including fermentation, chemical synthesis, extraction, bioengineering, traditional Chinese medicine and mixed assembly. At the end of 2004, our bureau issued the task of standard compilation, and established a standard compilation group led by Hebei Academy of Environmental Sciences, with the participation of Harbin Institute of Technology, East China University of Science and Technology, Standards Institute of State Environmental Protection Administration and other units. At the end of April, 2005, the Science and Technology Standards Department of the State Environmental Protection Administration held a demonstration meeting on six standard opening reports in Beijing. After that, the standard writing team went to typical pharmaceutical enterprises in Hebei, Heilongjiang, Jilin, Liaoning, Tianjin, Shandong, Guangdong, Hubei and other provinces to conduct field research, data collection and standard drafting. At present, the first draft standard has been formed. The opinions of all localities, departments and enterprises will be solicited in the near future.

Reporter: What specific requirements does the General Administration have for the formulation of pollutant discharge standards for the pharmaceutical industry?

Person-in-charge: The General Administration has the following requirements for industrial emission standards: First, highlight the pollution characteristics of the pharmaceutical industry and focus on controlling toxic and harmful substances harmful to human health and ecological environment; The second is to highlight industry pollution control technology and cleaner production technology, and promote the application of advanced technology in governance projects; Third, constantly improve the environmental access threshold, promote the structural adjustment of the pharmaceutical industry, and strive to keep up with the production level and advanced technology of advanced countries; Fourth, it embodies the principle of treating new and old sources differently, and the new source is strictly controlled, which embodies the advance and rolling.

Reporter: What needs to be done from start-up to the final introduction of emission standards?

Person in charge: According to the procedures and requirements for compiling national environmental protection standards, the compilation period of emission standards is generally two years, and particularly complicated projects can be extended appropriately. At present, the first draft of "Discharge Standard of Pollutants in Pharmaceutical Industry" has been formed. After discussion in a certain range, we will solicit opinions from the whole country, including environmental protection systems, industry associations, pharmaceutical companies, scientific research institutes and so on. All units and individuals who are concerned about the discharge standards of pollutants in the pharmaceutical industry can put forward opinions and suggestions. Our bureau will promptly organize the compilation team to study the opinions put forward by various units, revise and improve the standard text, and hold an expert review meeting to conduct technical review of the standard in due course. After the experts pass the examination and approval, our bureau will finally hold an examination and approval meeting and jointly issue it with the AQSIQ.

Reporter: What role do you think pharmaceutical companies should play in the process of standard preparation?

Person in charge: The emission standard is mandatory, and China's relevant environmental protection law has clearly stipulated that "excessive discharge is illegal". Therefore, the majority of enterprises should regard emission standards as the lifeline of enterprises, and regard meeting the emission standards as their due social responsibility. It is hoped that the majority of pharmaceutical enterprises will pay attention to and actively participate in the formulation of standards, make suggestions and suggestions, make the formulated standards more perfect and scientific, conform to the technical level and economic affordability of enterprise pollution control, and meet the requirements of national environmental management and pollution control.

Reporter: Finally, please introduce the purpose of the seminar on pollution prevention and control technology policy and emission standard in pharmaceutical industry sponsored by the General Administration.

Person-in-charge: In 2004, our bureau issued the meeting plan of "Seminar on Technical Policies and Emission Standards for Pollution Prevention and Control in Pharmaceutical Industry". The purpose of this meeting is to study the classification system of emission standards of pharmaceutical industry, discuss the first drafts of six standards, and exchange information on pollution control technology and cleaner production technology of pharmaceutical enterprises. It's a meeting for compiling pollutant discharge standards in pharmaceutical industry, and it's a meeting for unifying thoughts, soliciting opinions, exchanging information and improving.

National Environmental Protection Pharmaceutical Wastewater Pollution Control Engineering Technology Center

National Environmental Protection Pharmaceutical Wastewater Pollution Control Engineering Technology Center (hereinafter referred to as "Engineering Technology Center") is a technical functional institution approved by the State Environmental Protection Administration to carry out environmental protection work in the pharmaceutical industry, and the State Environmental Protection Administration conducts policy guidance and business management. Its main purpose is to provide technical support and services for solving major scientific and technological problems of environmental protection in the pharmaceutical industry, promoting the development of environmental protection high-tech industries, and realizing the environmental protection goals and sustainable development of ethnic pharmaceutical industries by building first-class R&D bases at home and abroad and using modern operating mechanisms.

At present, the Engineering Technology Center has an environmental science and technology innovation platform for pharmaceutical industry, which is mainly composed of central laboratory, process laboratory, pilot research base, productive experimental base and demonstration enterprise group, and integrates scientific research, process development, engineering design, equipment manufacturing, operation and debugging, and can condense and release the potential of joint research and development in Industry-University-Research.

The central laboratory is equipped with first-class analysis and testing instruments at home and abroad, such as GC-MS, LC, ICP-MS, TOC tester, AAS, FT-IR, and portable instruments such as COD, pH, ss and DO, which can realize the identification of toxic substances in pharmaceutical industry, the screening of biomarkers and the research of practical toxicology monitoring technology, and provide a basic research and analysis and testing platform for cleaner production and technological innovation of pollution prevention and control in pharmaceutical industry.

The process laboratory is equipped with nearly 100 sets of experimental simulation devices, including compound anaerobic granular bed reactor (HAR), CASS reactor and membrane bioreactor (MBR). Among them, the small test platform is designed according to the pollution characteristics of pharmaceutical wastewater and has advanced automatic control system. At the same time, each processing unit can be freely combined and switched, so as to process monitoring data and obtain process parameters to the maximum extent, and provide technical support and services for industry high-tech research and development and preliminary consultation of sewage treatment engineering design.

The pilot research base has many types of pharmaceutical wastewater sources, and is equipped with advanced high-efficiency anaerobic, aerobic, membrane bioreactor, water recycling and other medium-sized expansion test equipment, which can realize unit switching on demand, provide process parameters for the prevention and control of pharmaceutical wastewater pollution, the amplification of water recycling technology research results and the research and development of high-efficiency treatment equipment, and provide comprehensive transformation of scientific research results and rapid popularization and application of new technologies for scientific research holders, research units, engineering design units, pharmaceutical environmental protection enterprises.

The productive experimental base collects dozens of kinds of wastewater and solid wastes from many pharmaceutical enterprises, such as biopharmaceuticals, pharmaceutical chemical synthesis, etc., which can realize the amplification test of scientific research results to industrial application and the test of safe disposal of main pollutants, achieve the experimental verification purpose of overall process optimization combination and treatment efficiency and economic coupling, and provide long-term and stable technical reserves and support for the selection and optimization of wastewater treatment processes for different pharmaceutical varieties.

Relying on more than 70 enterprises such as Huabei Pharmaceutical and Shijiazhuang Pharmaceutical, the demonstration enterprise group covers the main categories such as fermentation, chemical synthesis, semi-synthesis, extraction, traditional Chinese medicine, bioengineering, preparations, etc., and provides a demonstration point for the transformation of new technological achievements in pollution control in the pharmaceutical industry, the industrialization of new and efficient technology and equipment, and the promotion of clean production processes, technologies and methods.

The "Engineering Technology Center" has determined a stable research direction, including the research and development and application of key technologies and complete sets of equipment for pharmaceutical wastewater treatment, the informationization and optimization of water resources management in pharmaceutical industry, the ecological safety of waste in pharmaceutical industry and the construction of emergency system for major accidents, the design and clean production of green products, and the research on technical policies and standards for pollution prevention and control in pharmaceutical industry. Based on the tenet of "socialization of R&D system, industrialization of scientific and technological achievements, commercialization of operation mechanism and marketization of development direction", the center mainly carries out R&D and industrialization projects of key technologies for pollution prevention and ecological protection; Building demonstration projects of new environmental protection technologies and popularizing advanced environmental protection technologies and products; Carry out technical exchanges and cooperation at home and abroad, and introduce, digest and absorb foreign advanced technologies and equipment; Cultivate senior environmental engineering and technical personnel and management personnel; To carry out research and formulation of technical policies, technical standards and norms for environmental protection in related fields; Undertake relevant engineering technical evaluation and engineering verification; Carry out environmental technical consultation and technical services.

"Engineering Technology Center" draws lessons from advanced operation and management experience at home and abroad, and initially forms an operation mechanism and management concept that can condense and release the combined R&D potential of "production, learning and research". Through mechanism innovation, the limited scientific and technological resources such as social scientific and technological human resources, scientific research material conditions and research and development funds are integrated, and according to the national scientific and technological development policy of "independent innovation, key leapfrogging, supporting development and leading the future", the scientific and technological demand topics are openly collected for the society in the research and development direction, and the chief experts are openly recruited for major research and development topics and projects. In the process of project implementation, the chief expert responsibility system is implemented, and outstanding scientific and technological personnel are organized to focus on tackling key projects in the pharmaceutical industry and strive to

Over the years, the Engineering Technology Center has carried out a series of research and engineering practice on pollution prevention and control technologies of high-concentration refractory organic wastewater in pharmaceutical and other industries. The technologies of hydrolysis acidification-membrane bioreactor for treating refractory high-concentration organic wastewater, anaerobic-aerobic bioreactor for treating organic wastewater, UASB reactor for comprehensively treating high-concentration organic wastewater, high-activity anaerobic granular sludge industrial production technology, high-sulfur biogas desulfurization technology, Vc wastewater anaerobic treatment reflux technology and high-efficiency internal circulation anaerobic reactor application technology were obtained. More than 40 achievements and technologies, including sulfur-containing organic wastewater treatment methods and special equipment for gas purification, Hb and penicillin residue organic fertilizer production technology. Among them, hydrolysis acidification-membrane bioreactor technology for treating refractory high-concentration organic wastewater, comprehensive treatment technology of high-concentration organic wastewater in UASB reactor with medium temperature rise, industrialized production technology of high-activity anaerobic granular sludge, treatment method of sulfur-containing organic wastewater and special equipment for gas purification have won national provincial and ministerial-level scientific and technological progress awards and invention patents.

Haizheng pharmacy

Constructing EHS system and taking the road of sustainable development

Zhejiang Haizheng Pharmaceutical Co., Ltd., founded in 1956, is one of the largest production bases of antibiotics and anti-tumor drugs in China, with seven categories of products, including anti-tumor, anti-parasite, cardiovascular system, anti-infection (including β -lactamase inhibitors), immunosuppressants, endocrine regulators and antidepressants.

Realizing the transformation of economic growth mode with circular economy as the starting point

Focusing on the idea of "reducing waste discharge, solvent consumption and production cost", Haizheng Pharmaceutical has vigorously developed circular economy and realized the transformation of economic growth mode.

Based on the existing solvent recovery, according to the quantity and nature of products that have been put into production and trial production and the use of various solvents, the company summed up experience and established a new organic solvent recovery center.

The company set up a fermentation workshop in Waisha Factory as a pilot to carry out energy-saving technical transformation of motor frequency conversion. The energy saving effect is remarkable, and the energy saving rate is above 12%. High-frequency harmonics, transient voltage and surge current in the power supply circuit are effectively suppressed, and the equipment failure rate is reduced.

By improving the reuse rate of cooling water and deionized wastewater, the company can reduce the water consumption of other links and achieve the purpose of saving water. At present, the company's external sand factory has reduced the total water consumption by nearly 50% through recycling water.

The company also comprehensively utilized and developed fermentation waste residue, added soybean meal to make it ferment again, developed organic fertilizer, turned waste into treasure and increased income. At present, the pilot test has been successful.

Focus on cleaner production and comprehensively improve equipment and technology.

In the process of cleaner production, Haizheng Pharmaceutical always takes improving the equipment and technical level as the focus of its work.

The reform of fermentation tail gas treatment system focuses on solving unorganized emission. The company adopts high-efficiency cyclone separation technology and water film spraying device to treat the exhaust gas from vacuum pump, induced draft fan and fermentation residue air drying, seals the sewage treatment station, and installs spray absorption device and biological desulfurization device, so that the gas separation efficiency is as high as 95%, and the gas discharged after separation is clean without fermentation liquid and foam, which meets the exhaust emission standard.

Using advanced microfiltration and nanofiltration equipment to pretreat the fermentation broth of tumor antibiotic products can improve the product yield by 20 ~ 30% and greatly reduce wastewater discharge. Therefore, the company plans to introduce foreign advanced membrane filtration equipment to carry out technical transformation on the workshop of Yantou Factory.

Based on structural adjustment, create the advantages of bio-industry

Haizheng Pharmaceutical always regards the adjustment of industry and product structure as the basis of fully implementing cleaner production. While continuously eliminating old products with serious pollution, we will develop new industries with high efficiency, low consumption, low pollution or basically no pollution.

The company strives to extend the industrial chain, focusing on developing high-tech products with low energy consumption, low pollution and high efficiency, and constantly expanding the R&D and production capacity of raw materials and pharmaceutical preparations. While exporting raw materials, the company accelerates the pace of raw materials entering the mainstream markets in Europe and America, and forms four emerging industries as soon as possible: natural drugs, export preparations, genetically recombinant drugs and R&D industry.

As a developing enterprise, Haizheng Pharmaceutical is currently facing the economic transformation from traditional development to scientific development. The company takes environmental protection, safe production and social harmony as the basic policy and sustainable development as the major strategy, and carries out large-scale activities such as source control, pollution prevention, risk assessment, cleaner production, health and safety, hazard identification, fire prevention and disaster prevention, community communication and so on throughout the company to promote the process of modern enterprise construction.