Brief introduction of cucurbitacin

Directory 1 pinyin 2 English reference 3 cucurbitacin overview 4 cucurbitacin quality standard 4. 1 method 4.2 character 4.3 identification 4.4 inspection 4.5 content determination 4.6 function and indication 4.7 usage and dosage 4.8 precautions 4.9 storage 5 cucurbitacin instruction 5. 1 drug name 5.2 English name 5.3 cucurbitacin alias 5.4 classification 5.5 dosage form 5.6 pharmacological action 5.

2 English reference Cueurbitacin[ Xiangya Medical Dictionary]

Cucurbitacin [Xiangya Medical Dictionary]

3 overview of cucurbitacin Cucurbitacin is an effective component extracted from the pedicel of traditional Chinese medicine melon (Syringa oblata) to treat hepatitis and liver cancer. It mainly contains cucurbitacin B and E, and its preparation is cucurbitacin tablets for oral administration. Clinical application can comprehensively improve the common symptoms and main signs of chronic hepatitis, with obvious effects of reducing enzyme (SGPT), turbidity (TTT, ZnTT) and bilirubin, without causing SGPT rebound after drug withdrawal, obviously correcting protein inversion and hyperglobulinemia, and improving nonspecific cellular immunity of patients with chronic hepatitis, without obvious toxic and side effects. Can be used for treating primary liver cancer, improving symptoms, eliminating liver pain, reducing tumor size, prolonging survival time, restoring physical strength, etc. It is superior to the western medicine 5- fluorouracil and has no toxic and side effects of general chemotherapy drugs.

4 Cucurbitacin Quality Standard Cucurbitacin This product is the extract of Cucurbitaceae plant melon pedicel.

4. 1 method: the pedicel of melon was extracted with ethanol, and the extract was concentrated to an appropriate amount, separated, refined and dried.

4.2 Properties This product is yellow-white powder; Tasteless and bitter. This product is soluble in chloroform and ethyl acetate, soluble in methanol and acetone, slightly soluble in ethanol, and almost insoluble in water and petroleum ether.

4.3 Identification (1) Take about 2mg of this product, add 5ml of ethanol to dissolve it, add 0.5ml of alkaline tetrazolium blue test solution and shake it well, showing rosy.

(2) Take about 2mg of this product, put it in a porcelain evaporating dish, add 1ml acetic anhydride, and slowly add a few drops of sulfuric acid along the dish wall. The solution changed from lavender to dark green and finally to reddish brown.

(3) Take an appropriate amount of this product, add ethanol to make a solution containing 25μg per 1ml, and determine it by spectrophotometry (Appendix ⅴ a). The maximum absorption wavelength is 228±2nm.

(4) Take 65438±0mg of this product powder and add 65438±0ml of ethanol to dissolve it as the test solution. Another cucurbitacin B reference substance was added with ethanol to prepare a solution containing 0.5 mg per kloc-0/ml as the reference substance solution. According to the TLC test (Appendix ⅵ b), absorb 5 μl of the above two solutions, respectively, spot them on the same silica gel GF254 thin-layer plate, use ethyl phenylacetate (2: 3) as the developing agent, unfold, take them out, dry them, and examine them under an ultraviolet lamp (254nm). In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.

4.4 Check that loss on drying takes this product and dries it to constant weight at 80℃, and the weight loss shall not exceed 4.0% (Appendix ⅸ g). Go 1. Residue on ignition takes 0g of this product and checks it according to law (Appendix ⅸ J), which shall not exceed 0.65438 0%.

Take the residual residue of heavy metal residue on ignition and check it according to law (Appendix ⅸ E Ⅱ). The content of heavy metal shall not exceed 20 parts per million.

4.5 The content shall be determined by high performance liquid chromatography (Appendix ⅵ d). The chromatographic conditions and system applicability were tested with octadecylsilane bonded silica gel as filler and methanol-water (62: 38) as mobile phase. The detection wavelength is 228 nm. Calculated by cucurbitacin B peak, the theoretical plate number should not be less than 2500. Preparation of reference solution Accurately weigh the right amount of cucurbitacin B reference substance, and make a solution containing cucurbitacin B0.03mg per kloc-0/ml with methanol. Preparation of test solution Take about 65438±00mg of this product, weigh it accurately, put it in a 50ml volumetric flask, add methanol to dissolve and dilute it to scale, and shake it evenly; Accurately measure 2ml, put it in a 10ml volumetric flask, add methanol to dilute to the scale, and shake well.

The determination method accurately absorbs 65,438 0.5 μ l of control solution and test solution, respectively, and injects them into a liquid chromatograph for determination. The content of cucurbitacin B(C32H46O8) in this product shall not be less than 60.0% in terms of dry product.

4.6 Functions and indications: detoxification and heat clearing, diuresis and jaundice elimination. It can be used for adjuvant treatment of persistent hepatitis, chronic hepatitis and primary liver cancer caused by excessive damp-heat toxin.

4.7 Usage and Dosage: Chronic hepatitis and chronic hepatitis 1 ~ 3 tablets once, three times a day, with three months as a course of treatment. Take it after meals, and reduce the amount of children. For primary liver cancer, take 2 ~ 4 tablets once, 3 times a day or as directed by the doctor, and take it after meals for three months as a course of treatment. Maximum: 6 tablets at a time.

4.8 Be careful not to increase the dosage at will, and pregnant women and those with severe digestive tract ulcers should avoid taking it.

4.9 Storage shall be sealed, sheltered and placed in a cool and dry place.

5 cucurbitacin instructions 5. 1 drug name cucurbitacin

5.2 English name cucurbitacin

5.3 cucurbitacin alias cucurbitacin e; Spray cucurbitacin; Ganlike cucurbitacin

5.4 classification of digestive system drugs >; Auxiliary drugs for liver disease

5.5 dosage form tablets: 0. 1mg per tablet.

5.6 Pharmacological Action of Cucurbitacin is an extract from the fruit stalk of Cucurbitaceae. The effective components are cucurbitacin B and cucurbitacin E. Cucurbitacin can stimulate cellular immune function, prevent fatty degeneration of liver cells and inhibit fibrous tissue proliferation. Has the effects of reducing enzyme, eliminating jaundice, eliminating ascites and improving protein metabolism.

5.7 Pharmacokinetics of Cucurbitacin (unclear)

5.8 indications of cucurbitacin in the treatment of chronic persistent hepatitis. Can also be used for treating primary liver cancer.

5.9 contraindication of cucurbitacin is prohibited for pregnant women or patients with severe peptic ulcer.

5. 10 Precautions Dose shall not be increased at will.

5. Adverse reactions of11cucurbitacin Some patients may have anorexia and epigastric discomfort at the initial stage.

The usage and dosage of cucurbitacin is 5. 12. Adults should take 0. 1 ~ 0.3 mg three times a day after meals. Children should be reduced. The general course of treatment is 2 months.

5. 13 drug interaction (unknown)

5. 14 Expert comments: Cucurbitacin can obviously reduce serum alanine aminotransferase, make liver function return to normal, and has obvious cholagogic and jaundice-relieving effects. It can also improve protein's metabolism and immunity, and has certain curative effect on chronic hepatitis and primary liver cancer.

Cucurbitacin-related drug cucurbitacin alias: cucurbitacin E; Spray cucurbitacin; Ganlike gourd classification: digestive system ...

Cucurbitacin ecurbitacin alias: cucurbitacin e; Spray cucurbitacin; Ganlike gourd classification: digestive system ...

Ganlike ucurbitacin alias: cucurbitacin e; Spray cucurbitacin; Ganlike gourd classification: digestive system ...

Cucurbitacin alias: cucurbitacin e; Spray cucurbitacin; Ganlike gourd classification: digestive system ...

Cucurbitacin tablets