If the main application for 485 visa is cancelled, the second application will be affected.

Visa 485 is an immigration document of the United States, which is used to adjust the non-immigrant status to permanent resident status. As far as I know, if the main applicant's 485 visa application is cancelled, the application of the deputy applicant may also be affected, but the specific situation needs to be determined according to the personal situation and the decision of the visa officer.

Usually, the 485 visa application of the deputy applicant is submitted based on the application of the main applicant. If the main applicant's application is cancelled or rejected, the sub-applicant's application may be regarded as associated with the main applicant's application, which may lead to the cancellation or rejection of the sub-applicant's application.

However, this situation is not absolute. The visa officer will make a decision according to the specific circumstances of each case. The agent applicants may need to provide additional supporting materials or interviews to prove that they are independent in obtaining the 485 visa. If the deputy applicants can prove that they meet the visa requirements and are not directly related to the main applicant's application, their applications can continue to be reviewed.

In short, if the main applicant's 485 visa application is cancelled, the application of the deputy applicant may be affected, but the specific situation needs to be determined according to the personal situation and the decision of the visa officer. It is recommended to consult a professional immigration lawyer for accurate legal advice and help.