Regarding the origin of Haibara Ai, in which "Conan" did his life experience appear?

First appearance:

Manga: Volume 18 of FILE.6 Transfer Student;

TV: 129 Murder Case of a Female University Professor from a Dark Organization, which contains Introduction.

About Haibara:

The second heroine of Shogakukan's ace work "Detective Conan" - Japan's second-generation Sanmu Queen - Haibara Ai, although she is not as good as Conan's reasoning ability, but her steady character and thoughtful wisdom hidden in that weak body, make people cherish her every line, every smile and every gaze.

My real name is Shiho Miyano, the daughter of father Atsushi Miyano and mother Irene Miyano (British), and an older sister who spends less time together and more separation: Agemi Miyano. Since their parents are both members of the dark organization, the two of them also became members of the organization. Shiho's organization codename is Sherry. Because he is one of the few top minds in the organization and is a scientific madman like his father, he is ordered to develop and manufacture poisons and conduct drug research. But at the same time, his father died in a car accident, and his mother's whereabouts were unknown. His sister was assassinated by Gin because she did not agree to the organization's requirements. After knowing this, Shiho betrayed the organization and swallowed a homemade poison: APTX-4869 (the one Shinichi took...) before being killed. He became smaller and successfully escaped from the garbage tunnel in the gas chamber where he was imprisoned by the organization. Escape. After coming out, desperate Shiho went to find her only hope: Kudo Shinichi. However, he fainted in front of the Shinichi family due to hunger and cold. After being taken in by the kind-hearted Dr. Agasa, when Shinichi became younger (that is, Edogawa Conan), he found the class he was in (that is, Grade 1 Class B) and changed his name. For: Haibara Ai.

Reason for shrinking: Because the organization killed her sister Miyano Akemi, she betrayed them and stopped drug research. After that, she was imprisoned by the organization like a gas chamber. He originally wanted to commit suicide by eating APTX4869, but he escaped by shrinking.

Comics Volume 18 TV129 The Woman from the Dark Organization.