Why did the Ming government give up its dominant position in the western regions (now Xinjiang)?

There are many reasons why the Ming Dynasty paid little attention to the Western Regions. Although Ming Chengzu always wanted to restore the rule of this area, this period was precisely the period when Uighur was strong. Hami Wei, the westernmost garrison of the Ming Dynasty, was occupied, so it was difficult for the Ming Dynasty to send troops to the west. Coupled with the weakening of the strength in the late Ming dynasty, especially the fear of foreign military soldiers by non-governmental organizations, the fighting capacity of the Ming army has also shrunk greatly. As for Mongolia, it's not a big problem. In fact, at the end of the Ming Dynasty, the strength of West Mongolia basically failed to surpass that of East Mongolia, and West Mongolia has been devastated since its death.