When can humans establish an interstellar empire? The science fiction topic has nothing to do with it and attracts keywords

Judging from the current situation, humans cannot live without the earth, even artificial gravity will not work. Various physiological indicators in the human body are actually closely connected with the solar system. The earth-moon system directly affects human physiological and even psychological cycles. If humans want to carry out safe space voyages with current technology, humans will probably have to make huge sacrifices and changes physically and even psychologically. The interstellar empire is a bit delusional.

It would be great if we could set up a permanent manned base station on another planet