Physical examination of high uric acid is not necessarily a gout attack, but you still need to understand the causes and harm of high uric acid in the blood.

Now gout is a common disease, and gout and hyperuricemia are paid more and more attention, including routine physical examination items, and now there are more blood uric acid. Some people think that once the blood uric acid is high, life will be bleak, while others think that gout is unlikely.

We all know that hyperuricemia is the basis of gout. If the uric acid value is too high, there will generally be no symptoms that you can feel. But if it is acute gouty arthritis, it is severe pain and redness. On the one hand, stay away from gout, on the other hand, there is no fear of high blood uric acid. Neither of these treatments is correct.

With regard to hyperuricemia, what we really need to fear is that if uric acid is too high's state persists, there may be various complications including gout. Today, Dr. Liu will tell you about the causes and harm of high blood uric acid.

What is uric acid? Uric acid is a weak organic acid, and its weak acidity comes from the ionization of the 9th hydrogen atom, while the 3rd, 1 and 7th hydrogen atoms seldom ionize. Nucleic acid, purine synthesized by ATP and purine ingested in food will be decomposed into uric acid, and once it is decomposed into uric acid, it cannot be decomposed again. It can be decomposed into uric acid, which will be excreted from the kidneys as "waste".

The process of uric acid production and excretion is called purine metabolism, and people call the substances produced in the process of human metabolism metabolic products, which cannot be decomposed and synthesized, nor can they be converted into other substances as metabolic end products. Uric acid is the final metabolite of purine, also known as the final product of life activities.

Generally speaking, there are two sources of uric acid in human body. Uric acid synthesized by small molecular compounds such as amino acids and nucleotides and decomposed by nucleic acids is called endogenous uric acid, which accounts for about 80% of the total uric acid in the body. Intake from foods rich in purine or nucleoprotein belongs to exogenous uric acid, accounting for about 20% of uric acid in the body.

Healthy people can produce about 750mg of endogenous uric acid and exogenous uric acid every day, while the average uric acid in uric acid pool in vivo is about 1200mg, and about 500~ 1000mg of uric acid is excreted every day, of which about 2/3 is excreted in urine, and 1/3 is excreted in intestine or decomposed by bacterial uric acid oxidase.

Serum uric acid is an important indicator of life. Epidemiological studies show that the serum uric acid level of adult males is 420μmol/L, and that of females is higher than 360μmol/L, which means that the serum uric acid level is increased. The normal reference range of serum uric acid in women is 89~360μmol/L, and that in men is149 ~ 417 μ mol/L.. Of course, different hospitals will be slightly different because of different testing instruments, test strips and testing methods.

Generally speaking, under normal physiological conditions, at least 98% of uric acid in blood exists in the form of monosodium urate monohydrate, and its solubility is about 384 μ mol/L. In addition, 4%~5% can be reversibly combined with plasma protein. Therefore, the maximum solubility of monosodium urate monohydrate in blood is 408μmol/L, and once it exceeds 420μmol/L, it may be deposited in joints, cartilage, synovium, joints and other tissues and cause diseases.

Therefore, in clinic, both men and women are diagnosed as hyperuricemia when the fasting blood uric acid level reaches 420μmol/L twice on different days under the normal purine diet.

Hyperuricemia is the main biochemical feature of gout. The higher the blood uric acid level, the greater the probability of gout. It is found that about 10% patients with hyperuricemia will have symptoms related to the increase of uric acid, such as arthritis, tophus or renal damage. Therefore, once hyperuricemia occurs, the doctor will recommend relevant treatment.

The treatment here is mainly non-drug treatment, that is, life conditioning, including not overeating, not starving and dieting, not using too much high-purine, high-calorie, high-fat food, and not drinking alcohol.

Why does blood uric acid rise? It is mainly the enhancement of purine anabolism or (and) the decrease of uric acid excretion, which is the primary mechanism of the increase of serum uric acid in patients with hyperuricemia and gout.

As we said before, under normal circumstances, the production and elimination of uric acid are in a dynamic balance, that is, the serum uric acid is maintained below 420μmol/L, while the uric acid pool is maintained at around 1200mg. However, if uric acid production increases, the growth rate or (and) excretion decreases or slows down; Or excrete more uric acid than normal people, but the amount of uric acid produced exceeds the excretion rate, which can increase the blood uric acid concentration.

That is to say, excessive uric acid production and intake or (and) decreased excretion caused by any reason may lead to an increase in blood uric acid concentration. Hyperuricemia and gout are metabolic diseases and lifestyle-related diseases. A large number of studies also show that gout is a polygenic genetic disease, and its onset is the result of the interaction of genetic factors and environmental factors.

In other words, the increase of serum uric acid is mainly caused by many factors, including genetic factors and environmental factors. Moreover, related factors will not only cause high uric acid, but also cause diseases such as hypertension, hyperlipidemia and hyperglycemia. Moreover, after finding out the causes of hyperuricemia and gout, we can also take relevant treatment methods for symptomatic treatment.

Generally speaking, we call hyperuricemia the "fourth highest" after hypertension, hyperlipidemia and hyperglycemia. These diseases are also called metabolic syndrome together with obesity. That is to say, although hyperuricemia is called the chief culprit of gout, it may also cause other related diseases.

The hazards of hyperuricemia mainly include:

It is precisely because hyperuricemia is prone to the above hazards, so we suggest that once the blood uric acid rises, the uric acid value should be controlled in time. In other words, hyperuricemia occurs not only to prevent gout attacks, but also to prevent serious complications. Therefore, the uric acid value should be controlled within the normal range anyway.

Patients with hyperuricemia have uric acid below 540μmol/L, and have no cardiovascular and cerebrovascular diseases. Therefore, the lifestyle can be improved and the uric acid value can be controlled within the normal range. However, when the serum uric acid exceeds 540μmol/L or the serum uric acid exceeds 480μmol/L with acute attack of cardiovascular and cerebrovascular diseases and gout, it is necessary to receive medical treatment, needle knife mirror treatment, immunoadsorption treatment and so on.

Hyperuricemia or hyperuricemia is a disease with abnormal biochemical indexes and no clinical symptoms. Each of us may have hyperuricemia, but as long as we maintain a healthy lifestyle, it is possible to reduce uric acid, or we may not suffer from gout for life. Remember the harm of high uric acid and change your lifestyle.