What challenges do you face when the normalization of nucleic acid testing is required everywhere?

Long-term monitoring of millions of samples will greatly test the time and energy of sampling and testing personnel and the standardization of actual operation. In fact, compared with the rapidity and timeliness of hardware facilities such as nucleic acid detection sampling kiosks and PRC gene amplifiers, many authoritative public health experts have said that it is the most difficult to recruit, research and train qualified employees in a short time.

On May 9th, the "Domain Weekly" published by Shanghai Securities wrote that at least 750,000 detection points should be added nationwide in order to better complete the normal nucleic acid detection, only considering the urban population. Accordingly, at least several million nucleic acid samplers are needed.

The huge information of the checklist also supports the rapid expansion of this field. In May 2022, the news that a third-party nucleic acid testing institution in Chaoyang District of Beijing was quickly approved attracted public attention. Since then, the Chaoyang District Health and Health Commission has replied that there is a vacancy in the nucleic acid detection capacity in this area, which has accelerated the review of testing institutions. Sky survey shows that the organization was founded on April 26th. On May 3rd, Chaoyang District Health and Health Commission issued a license for designated medical institutions, and on May 4th, the company was allowed to carry out nucleic acid testing.

In the report of May 20021,Gaohe Investment Research Center, which has long invested in the diagnosis and treatment industry, wrote that the field of third-party medical inspection technology is mixed and the development trend is uneven. More than 90% of the business scale is small, and there are long-term problems such as irregular commodity sampling, uncontrollable logistics and transportation quality, and uncontrollable sample quality.

According to reports, from March 20 10/2 to March 26, 2022, the Wei Jian Department conducted 46/kloc-0 inspections on 59 medical and drug inspection laboratories, and found that more than 50 laboratories were not in compliance with regulations. Among them, there are problems in the qualification certificate of inspectors, such as a few young volunteers with or without PCR qualification certificate participating in important links of testing, and there are also cases in which the testing steps are not standardized.

On May 29th, the press conference on prevention and treatment of COVID-19 held in Beijing said that Beijing Zhongtong Rambo Medical Inspection Co., Ltd. had seriously violated the COVID-19 inspection operation standard and illegally conducted mixed tube inspection on multi-tube samples. On May 27th, according to the official report, from April 25th, 2022 to now, Beijing Jinzhun Medical Inspection Institute has illegally detected "5- mixed 1" and "1 mixed1"nucleic acid samples collected in many areas by multi-tube mixed detection, and diluted the samples, which endangered the accuracy of the detection conclusion. Beijing police have sued the enterprise.

On the same day, Daqing Yang, director of the Office of Fangshan District Health and Wellness Committee in Beijing, and others were investigated for serious violations of discipline and discipline during the supervision of Platts Medical Laboratory in Beijing. Previously, Park Stone Medical Laboratory was informed that due to suspected data fraud, the initial test data information was significantly lower than the total number of sample tests, and the practice license of medical institutions was cancelled.

Some new attempts are also being made on a large scale. Jiangsu, Zhejiang, Anhui, Shanxi and other places have organized pharmacies to undertake daily sampling tasks. Compared with the construction of nucleic acid detection points and the large-scale recruitment of volunteers, social health pharmacy has the natural advantages of joining chains, fixed places and stable personnel, which can enlarge and strengthen the network resources of professional pharmacists, improve sampling efficiency and control costs.

Not long ago, Zhang Wenhong wrote that the sensitivity of antigen detection for self-examination is not as high as that of nucleic acid, and it must be further improved if it is used for dynamic clearance. The international community is also exploring the nucleic acid detection methods of domestic self-examination, and the future is also worth looking forward to.

In the long run, the normal prevention and control of COVID-19 epidemic should be based on innovation and scientific and technological strength. Lu Hongzhou said, for example, his elite team has developed a mouthwash for nucleic acid detection, which allows residents to sample independently. The robotic arm sampling developed by Shanghai Institute of Artificial Intelligence does not need actual operation, and it can take a nucleic acid sampling in about 30 seconds. Intelligent robot sampling can also be equipped with a self-service mobile nucleic acid sampling vehicle, which can reduce the infrastructure of fixed sampling positioning points.

Lu Hongzhou emphasized that in order to completely change "passive" into "active" in the future, there is no need to screen normal nucleic acids, or even get rid of the COVID-19 epidemic. The key is to create group immunity by maintaining vaccines with high legal efficacy and high efficiency, and to take small molecular water antiviral drugs orally to reduce critical illness. In this way, we don't have to worry about the large-scale COVID-19 epidemic rebound, and gradually ease.