Similarities between Zuojin Pill and Longdan Xiegan Decoction

Open classification: drugs, drugs, Chinese patent medicines and prescriptions.

Drugs for spleen and stomach diseases

Fang Ming Zuo Jin Wan

Source "Danxi Heart Method"

Hui Ling Pill (Volume I of Danxi Heart Method) and Julian Pill (Collection of Medical Prescriptions).

Classified heat-clearing agent-Qingzang fever

It consists of Coptis chinensis (180g) and Evodia rutaecarpa (30g).

formula

Function: clearing liver and purging fire, reducing adverse reactions and stopping vomiting.

Indications: Liver-fire attacking the stomach. Hypochondriac pain, noisy acid swallowing, expectoration, red tongue with yellow coating and rapid pulse. (This prescription is commonly used for patients with gastritis, esophagitis, gastric ulcer and other liver fire. )

Usage: Soak into pills with water at the end, 2-3g each time, and take with warm boiled water. It can also be decocted, and the dosage is determined according to the original proportion.

Taboo consideration.

The syndrome of this prescription is caused by stagnation of liver-qi transforming into fire, stomach inversion and disharmony between liver and stomach. The meridians of the liver are distributed in the ribs, and the ribs swell and ache when the liver meridians are sick; Offending the stomach causes the stomach to lose its balance, so it is sour and bitter, and it is noisy; Red tongue with yellow fur and thin pulse are symptoms of liver meridian stagnation. Su Wenzhi's Theory of Truth says: "All opposites are fire"; "All acid regurgitation, sudden injection and compulsion belong to heat." Fire should be clear, and qi should be reversed, so the treatment should focus on clearing liver and purging fire, and mainly on stopping vomiting. In the prescription, Rhizoma Coptidis is the monarch, clearing liver and purging fire, which can clear liver and purging fire without offending stomach; Coptis chinensis is also good at clearing stomach heat, reducing stomach fire, and harmonizing its qi. One medicine can clear liver and stomach, and treat both the symptoms and root causes. However, for the syndrome of qi stagnation and excessive fire, if only great bitterness and cold are used, it is afraid that stagnation will hurt zhongyang, so adding less Evodia rutaecarpa, pungent heat, soothing the liver and relieving depression can achieve liver qi and relieving depression; On the other hand, it helps to control the coldness of Coptis chinensis, so that purging fire is not cold; One of them is used to reduce qi, so as to harmonize with stomach and reduce adverse flow; One can lead coptis into the liver meridian. So blindly add four functions, I thought it was an assistant. The combination of the two drugs can clear liver and purge fire, reduce adverse reactions and stop vomiting.

The compatibility of this prescription is characterized by pungent and bitter taste, simultaneous treatment of liver and stomach, no cooling due to purging fire, no obstruction of fire depression due to descending adverse flow, on the contrary, they complement each other, clearing the liver, purging fire and reducing stomach qi, and then all the symptoms will heal themselves.

One of our prescriptions, Hui Ling Pill, is also called Yu Lian Pill.

Zuojin Pill and Longdan Xiegan Decoction are both suitable for excess fire in liver meridian, hypochondriac pain and bitter taste. However, Zuojin Pill is mainly used for vomiting and acid swallowing caused by stagnation of liver meridian fire, which has the effect of reducing adverse flow and regulating stomach, but it has no effect of clearing damp-heat and has a weak effect of purging fire. Longdan Xiegan Decoction is mainly used for the symptoms of red eyes and deafness caused by excess fire in liver meridian, or pruritus due to damp-heat downward flow. It has the function of clearing damp-heat, but it has no effect of regulating stomach and lowering adverse flow, and has a strong effect of purging fire.

According to the prescription, the syndrome of this prescription is caused by liver failure, depressed fire and liver fire invading the stomach. In the prescription, Rhizoma Coptidis is bitter, cold and purging fire, and Evodia rutaecarpa with pungent and hot taste can not only alleviate adverse reactions, stop vomiting, inhibit acid and relieve pain, but also restrict the coldness of Rhizoma Coptidis. The two flavors are synergistic, one is clear and one is warm, and the bitterness is reduced, achieving the effect of complementary opposites.

The dosage ratio of Coptis chinensis and Evodia rutaecarpa is 6∶ 1. For patients with severe acid swallowing, cuttlefish bone and calcined concha arcae are added to make acid and relieve pain; For patients with severe hypochondriac pain, Sini powder can be used to strengthen the function of soothing liver and stomach.

Attached are Wuji Pill (Taiping Huimin Hutchison Bureau) and Xianglian Pill (Taiping Huimin Hutchison Bureau).

Note: This recipe is often used to treat liver-fire invading the stomach and disharmony between liver and stomach. In clinical application, vomiting, acid swallowing, hypochondriac pain, bitter taste, red tongue with yellow coating and number of pulse strings are the key points of syndrome differentiation.

Prescription comparison:

Zuojin Pill, Wuji Pill and Xianglian Pill have the same compatibility method for relieving pain. The differences are as follows: Zuojin Pill Coptidis Rhizoma is 6 times as much as Evodia rutaecarpa, and its emphasis is on clearing liver-fire and regulating stomach-fire, which is mainly used to treat hypochondriac swelling and pain, vomiting and acid swallowing of liver-fire syndrome; Wuji Pill has the same dosage as Yu, that is, it pays equal attention to clearing heat and relieving depression, and adds Radix Paeoniae Alba to relieve anxiety. It is mainly used to treat stomachache, acid swallowing, abdominal pain and diarrhea caused by disharmony between liver and spleen. After frying Wan Lian and Wu, it is intended to clear away heat and dry dampness. Radix aucklandiae is added to promote qi circulation and relieve pain, and it is mainly used for treating damp-heat dysentery, purulent bloody stool and abdominal pain which is acute and then severe.

On Janice's "Jin Jian Yi Jia Fang" (Volume 4): "Zuo Jinwan takes Huanglian as the monarch alone, which is actually to save the child and break the inflammation. Evodia rutaecarpa (Evodia rutaecarpa) seeks help from the same kind, induces fever, relieves depression with pungent dryness, and punishes its Han, so it is considered as an adjuvant medicine. But if the spirit is true, it is appropriate. "

"Danxi Heart Therapy" Volume 1: "Liver fire and hypochondriac pain."

Traditional Chinese medicine name

Zuojinwan

Pinyin name

Zuojinwan

Character; Role; letter

This product is a yellow-brown water pill; Odd breath and bitter and pungent taste.

distinguish

(1) Take this product, and observe it under the microscope: the fiber bundle is bright yellow, with a slightly thick wall and obvious pits.

Non-glandular hair 1 ~ 9 cells, some of which are filled with reddish-brown substances; The head of glandular hair is multicellular, oval, with brownish yellow to brownish red, and the handle has 2 ~ 5 cells.

(2) Take 65438 0 g of this product, crush it, add 65438±00ml of ethanol, heat and reflux it for 65438 0 h, let it cool, filter it, and take the filtrate as the test solution.

In addition, taking 0. 1g Evodia rutaecarpa as the control medicinal material, the control medicinal material solution was prepared by the same method.

Then take berberine hydrochloride reference substance, add ethanol to make a solution containing 65438±0mg per 65438±0ml as reference substance solution.

According to the thin-layer chromatography test (Appendix ⅵ b), absorb 2μl of each of the above three solutions, respectively spot them on the same silica gel G thin-layer plate, and use benzene-ethyl acetate-methanol-isopropanol-concentrated ammonia water test solution (6: 3:1.5: 0.5) as the developing agent, and put them in the chromatographic cylinder of saturated ammonia vapor.

In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials; At the position corresponding to the chromatogram of the reference substance, the same yellow fluorescent spots appeared.

prescription

Coptidis Rhizoma 600g Evodia rutaecarpa100g

prepare

Pulverizing the above two medicines into fine powder, sieving, mixing, making pills with water, and drying.

cheque

Should comply with the relevant provisions of the pill (appendix 1A).

Content determination

Take the powder of this product about 1g (pass through No.3 sieve), weigh it accurately, put it in Soxhlet extractor, add a proper amount of hydrochloric acid-methanol (1: 100), and heat and reflux extract until the extract is colorless.

Transfer the extract (concentrate if necessary) to a 50 ml volumetric flask, add hydrochloric acid-methanol (1: 100) to dilute to scale, and shake well.

According to the column chromatography (Appendix ⅵ c) test, accurately measure 5ml, put it on the treated neutral alumina column (the inner diameter is about 0.9cm, 5g of neutral alumina, packed in the column by wet method, and pre-washed with 30ml of ethanol), elute with 25ml of ethanol, collect the eluent, put it in a 50ml volumetric flask, dilute it to scale with ethanol, shake well, accurately measure 2ml, put it in a 50ml volumetric flask, and add sulfuric acid solution.

The absorption coefficient of C20h18clono4 (e1cm1%) was calculated to be 728 according to the absorbance measured at the wavelength of 345nm by spectrophotometry.

In terms of dry product, the total alkaloid content of this product is not less than 6.0% in terms of berberine hydrochloride (C20H 18ClNO4).

Functions and instructions

Purging fire, soothing liver, regulating stomach and relieving pain. It can be used for disturbance of liver fire, hypochondriac pain, bitter and noisy mouth, spitting sour water, and aversion to hot drinks.

dosage

Oral, 3 ~ 6g once, twice a day.

store

Sealed against moisture.

Decoction of Gentian to Purge the Liver

Open classification: traditional Chinese medicine and prescription

Fangming Longdan Xiegan Decoction

The source of "Collection of Medical Prescriptions" is quoted from "Taiping Huimin and Hejiju Prescriptions".

Classified heat-clearing agent-Qingzang fever

Radix Gentianae (6g), Radix Scutellariae (9g), Fructus Gardeniae (9g), Rhizoma Alismatis (12g), Caulis Akebiae (9g), Semen Plantaginis (9g), Radix Angelicae Sinensis (8g), Radix Rehmanniae (20g), Radix Bupleuri (10g) and Radix Glycyrrhizae (6g).

The formula is fried with Radix Gentianae, Qin Zhi wine, Akebia Akebia, Alisma orientalis and firewood, and Radix Angelicae Sinensis is used for nourishing yin and blood, strengthening liver and gallbladder, and eliminating damp heat.

Function: Purging excess fire in liver and gallbladder, clearing damp-heat in lower energizer.

Indications: imbalance of excess fire in liver and gallbladder, with symptoms of headache, red eyes, hypochondriac pain, bitter taste, deafness and ear swelling; Or damp-heat betting, with symptoms of yin swelling and itching, muscle weakness and hyperhidrosis, turbid urine, and damp-heat leukorrhagia in women. (This prescription is commonly used for intractable migraine, eczema of the head, hypertension, acute conjunctivitis, iridocyclitis, furuncle of external auditory canal, rhinitis, acute icteric hepatitis, acute cholecystitis, urogenital inflammation, acute pyelonephritis, acute cystitis, urethritis, vulvitis, orchitis, inguinal lymphadenitis, acute pelvic inflammatory disease, herpes zoster, etc. It belongs to excess fire and damp-heat in liver meridian. )

Usage: decoction, the dosage depends on the severity of the disease. It can also be made into pills, 6-9g each time, twice a day, and taken with warm water.

This prescription is mostly bitter and cold, and it is easy to hurt the spleen and stomach every time it is taken orally, so it is not suitable for the syndromes of spleen and stomach deficiency and yin deficiency and yang hyperactivity.

Radix Gentianae in the prescription is good at purging liver and gallbladder fire, and can clear damp-heat in lower energizer. Scutellaria baicalensis Georgi, Gardenia jasminoides Ellis and Bupleurum chinense are bitter cold and purging fire, while Plantaginis Semen, Akebia Akebia and Alisma orientalis are all ministers. The liver is the dirty of storing blood, and the heat of liver meridian is easy to hurt yin blood, so Radix Rehmanniae and Radix Angelicae Sinensis are used to nourish blood and benefit yin. Glycyrrhiza uralensis Fisch blends various drugs. In the formula, * * * plays the role of purging excess fire in liver and gallbladder and clearing away damp-heat in liver.

This recipe treats excess fire in liver and gallbladder and disturbance of damp-heat in liver meridian. If you are disturbed, you will feel headache and ear pain, or be deaf; A mouth with pain and bitterness on one side and two sides; Betting is accompanied by swelling, pain and itching caused by the yin collateral of the liver meridian of foot Jue Yin. Damp-heat pouring into bladder is a symptom such as gonorrhea. Therefore, gentian is used in the prescription, which is bitter and cold, purging the liver and gallbladder with excess fire, and purging the lower energizer with damp heat. It is two kinds of monarch drugs that are good at purging fire and eliminating dampness. Scutellaria baicalensis Georgi and Gardenia jasminoides Ellis have the function of bitter cold and purging fire, and Gentiana scabra is the traditional Chinese medicine. Alisma orientalis, Akebia Akebia and Plantago asiatica clear away heat and promote diuresis, so that damp heat can be discharged from waterways. The liver governs the storage of blood, and the liver meridian is hot, which is easy to consume yin and blood. Adding bitter cold and dampness will consume yin, so Radix Rehmanniae and Radix Angelicae Sinensis are used to nourish yin and blood, so as to give consideration to both specimens. The prescription design of Bupleurum is to introduce various drugs into the liver and gallbladder, and Glycyrrhiza uralensis Fisch has the function of harmonizing various drugs. Look at the whole prescription, that is, there is a supplement in diarrhea and a supplement in benefit, so that the fire can be reduced to clear away heat, and the syndromes caused by meridians can be cured accordingly.

If the liver and gallbladder fire is flourishing, you can go to Akebia stem and Plantago seed and add Coptidis Rhizoma to help purge the fire; If the dampness is excessive and the heat is weak, Scutellaria baicalensis Georgi and Radix Rehmanniae can be removed, and talc and Coicis Semen can be added to enhance the diuretic effect; If the jade stem is sore, or the stool is toxic, the scrotum is swollen and painful, and the red heat is very heavy, you can go to Bupleurum, and add Forsythia, Coptidis Rhizoma and rhubarb to purge the fire and detoxify.

Fuxieqing Pill, Danggui Longhui Pill

Note: This recipe is often used to treat hyperactivity of liver meridian caused by hyperactivity of excess fire and downward flow of damp-heat. Clinical application takes bitter taste, red tongue with yellow fur and strong pulse string as the key points of syndrome differentiation.

Prescription comparison:

Longdan Xiegan Decoction, Xieqing Pill and Danggui Longhui Pill are all medicines for purging liver meridian fire. Their differences are as follows: Longdan Xiegan Decoction can purge liver fire, clear damp heat, nourish yin and blood, and eliminate evil without injury. Xieqing Pill purges liver fire, can disperse liver and gallbladder stagnation fire, and is suitable for liver fire stagnation syndrome; Danggui Longhui Pills concentrate on purging excess fire and divide it into two stools. Danggui Longhui Pill is an antidiarrheal agent. It is used to treat liver meridian syndrome due to excess fire, and should not be used lightly unless excess fire prevails.

Janice et al. were described in the literature as: "hypochondriac pain, bitter taste, deafness and ear swelling are diseases of the gallbladder meridian. Muscle weakness and damp, hot itching and swelling, white turbidity and bleeding are diseases of liver meridian. Therefore, Radix Gentianae purges the fire of the liver and gallbladder, Radix Bupleuri is the liver ambassador, Radix Glycyrrhizae relieves anxiety of the liver, and Qin, Fructus Aurantii, Tong, Ze and Che are the assistants to relieve yin, so that all damp heat can be caused. However, they are all liver-clearing products. When the disease is gone, the liver is injured. So add angelica, Radix Rehmanniae to nourish the liver, and the liver is covered with blood, so enrich the blood. The wonderful thing is that the medicine for purging the liver is used as a medicine for nourishing the liver, which means defeating the marrow. " Jin Jian of Medical Sect: On the Prescription of Deleting and Supplementing by Famous Doctors

Various exhibitions

1. Collection of Medical Prescriptions: This medicine is also used to tonify Jue Yin and Shao Yang. Radix Gentianae purges the heat of Jue Yin, Radix Bupleuri calms the heat of shaoyang, Radix Scutellariae and Fructus Gardeniae clears lung and triple energizer, Alisma orientalis purges the dampness of kidney meridian, Caulis Akebiae and Plantago asiatica purges the dampness of small intestine and bladder, so they are all medicines for diarrhea due to bitter cold. Therefore, they are used as ministers to nourish blood and liver, and licorice is used to soothe the middle energizer without hurting the stomach.

2. Revise the popular Treatise on Febrile Diseases: the liver is windy and wood, and the gallbladder is burning. Where liver qi is abundant, gallbladder fire occurs, and there are many symptoms, such as bitter mouth and hypochondriac pain, deafness and ear swelling, damp and itching, red blood in urine, and even muscle weakness and yin pain. Therefore, bravery, sparseness, gardenia and qinchun are kings; However, if the fire is strong, the yin will be deficient, so I use fresh land to make it sweet, cool and moist, and save the liver yin to relieve the liver's worries; The wonderful thing is that Bupleurum is light and clear, and it must be clearing the heart and calming the nerves; Make Alisma orientalis and Plantago asiatica salty and wet, and lead to liver and gallbladder fire. This is a good prescription for cooling liver and purging fire, guiding red and saving yin. But only when the liver and gallbladder are full of fire, the vaginal fluid is not dry, the pulse is numerous, and the tongue coating is purple and yellow and greasy.

3. synopsis of the golden chamber: hypochondriac pain, bitter taste, deafness and ear swelling are diseases of the gallbladder; Muscle weakness and damp, hot itching and swelling, white turbidity and bleeding are diseases of liver meridian. Therefore, Radix Gentianae is used to purge the fire of liver and gallbladder, Radix Bupleuri is used as the liver ambassador, Radix Glycyrrhizae is used to relieve liver anxiety, and Qin, Fructus Aurantii, Tong, Ze and Che are used to help damp heat. But they are all products of purging liver. When the disease is gone, the liver will be injured, so add Angelica sinensis and Radix Rehmanniae to nourish the liver. Covering the liver is the viscera of blood, and enriching blood is nourishing the liver. The wonderful thing is that the medicine for purging the liver, on the contrary, is a medicine for nourishing the liver and has the meaning of overcoming the need of relaxing menstruation.

4. "Easy to read": The husband's fire is caused by the liver and gallbladder, and his sex is easy to move and his movements are very loud. It's multiple syndromes. Or people's liver yin is insufficient, and the fire element is strong. At the time of the commander-in-chief of Six Dampness and Heat, the internal and external factors caused each other, and the qi was born together, so the meridians crossed by the liver and gallbladder and the meridians dominated by them were all harmed. Therefore, Gentiana scabra tastes bitter and cold, and purges the liver, gallbladder and damp fire; Liver and gallbladder belong to wood, wood is happy, evil fire is depressed, and wood is uncomfortable. Therefore, Bupleurum is used to soothe the liver and benefit the gallbladder, Scutellaria baicalensis is used as the ambassador, followed by Akebia stem, plantain and Alisma orientalis to induce pathogenic heat in small intestine and bladder. In ancient times, both positive and negative factors must be taken into account in treating diseases, otherwise, the evil will be removed from the negative, which may lead to the disadvantages of drugs. Therefore, when you go home, you should nourish liver blood, licorice can slow down the middle qi, and all kinds of medicines should cooperate, so that the bitter cold will not hurt your stomach, gas and ears.

5. "Lecture Notes on Qianzhai Medicine": This prescription takes Gentiana as the monarch, with Scutellaria baicalensis Georgi and Shan Zhi, purging liver and gallbladder fire; Akebia stem, plantain and Alisma orientalis are used to clear away heat and promote diuresis, Radix Rehmanniae and Radix Angelicae Sinensis are used to prevent fire from damaging yin, then licorice and Chinese herbal medicines are used to detoxify, and Bupleurum is used to guide menstruation and disperse qi. The general function is to astringe bitter cold, purge liver fire and clear damp-heat in lower energizer. Therefore, it can be used to treat hypochondriac pain, bitter taste, red eyes and deafness. It can also treat damp-heat syndrome such as dripping urine, swollen vagina and itching.

Source: The Secret Collection of the Blue Room.

Different names of Qiwei Longdan Xiegan Decoction (Volume 57 of Jingyue Quanshu) and Longdan Decoction (Volume 4 of You You You Integration).

Consists of 3 grams of Bupleurum, 3 grams of Alisma orientale, 65,438 grams of Plantago asiatica, 0.5 grams of Radix Rehmanniae, 9 grams of Radix Angelicae Sinensis and 9 grams of Radix Gentianae.

In use, the file is as big as a bean. Make one, use 450ml of water, fry it to 150ml, take it out of me, and take it with good dishes when it is warm on an empty stomach.

Clearing away dampness-heat in liver and gallbladder.

Indications for sore throat caused by excess fire in liver meridian; Damp-heat pours into the liver meridian, causing astringent and painful urination, pruritus in the pudendal region and foul smell.

It consists of 4.5g of Bupleurum, 4.5g of green tangerine peel, 4.5g of gentian, 4.5g of gardenia, 4.5g of rhubarb, 4.5g of white peony root, 4.5g of Akebia stem, 4.5g of forsythia suspensa, 4.5g of coptis root and 4.5g of talc. ..

Syndrome differentiation of damp-heat in liver and gallbladder.

Treat damp-heat, soothe the liver and promote qi circulation.

Usage: decoct with water, 1 dose, twice a day.

Other categories

Source: Selected Topics, Volume 4