The Development Course of Hunan Huari Pharmaceutical Co., Ltd.

Hunan Huari Pharmaceutical Co., Ltd. was originally a pharmaceutical factory in Ningxiang County, Hunan Province. Located at No.24 Bayi Road, Yutan Town, Ningxiang County, Changsha City, Hunan Province.

Ningxiang Pharmaceutical Factory is a branch of Ningxiang Petrochemical General Factory, which was founded in 1979. Ningxiang Pharmaceutical Chemical Plant was formed by the merger of timber mills on 1980, and declared as Ningxiang Pharmaceutical Factory on 1992, which was officially approved by the provincial health department, provincial, municipal, pharmaceutical and drug supervision departments and has the status of an independent legal person.

Production and business scope: antibiotic tablets, vitamin tablets, anti-inflammatory hormone tablets, antiseptic ointment, dermatological preparations, anti-infection tablets, yellow and white vaseline, brake oil, medical potassium citrate and sodium citrate.

In the early days of the establishment of the pharmaceutical factory, sodium citrate was developed and produced, from the annual output of 1 1,000 tons to the production capacity of 1 1,000 tons, with a maximum output of 8,000 tons. Later, potassium citrate (pharmaceutical raw material) was developed and produced. The actual annual production capacity was 1500 tons, and the best year hovered around 1000 tons. At the time of design, the annual output was 200 million pieces, and the highest one was about 40 million pieces. There is also a production line of medicinal yellow vaseline with an annual output of 65,438+0,000 tons, as well as production equipment such as ointment and dermatology drugs.

Since the establishment of 1987, the pharmaceutical factory has devoted itself to developing citric acid series products-citric acid, sodium citrate and potassium citrate (raw materials), and achieved good results, ranking the best level in the same industry in China at that time, and the product quality won the provincial excellent product. 90% of the sales customers are exported, and the economic benefits are increasing year after year. It is the main backbone factory under the General Petrochemical Plant. In the production of pharmaceutical preparations, the market in the province was satisfied at that time, mainly producing a small amount of oxytetracycline (tablets), erythromycin (tablets, ointment), urea ointment (milk), benzalkonium bromide, prednisone acetate (tablets) and berberine hydrochloride (tablets); , vitamin B 1 (tablets), vitamin C (tablets, injections), tetracycline (tablets, ointments, eye ointment), sulfur ointment, fish fat (ointment), iodine tincture, etc. Due to the chaotic market at that time, pharmaceutical production did not develop greatly, and 1995 basically stopped production. Award-winning digital citric acid (citric acid) series products have been produced so far.

1996 The pharmaceutical factory located in downtown cannot meet the needs of production development, and there are factors that affect the life and study of nearby residents and students. The general factory decided to rebuild within the scope of the general factory. Workshop area10000m2. 1996 Relocation completed in the second half of the year. Due to the shortage of funds, 1997 10 pharmaceutical factory is in a state of suspension.

May 25th, 20001year, Hunan Drug Administration Wholesale: Reply on Agreeing to Rename Ningxiang Pharmaceutical Factory (Hunan Drug Administration Anfa [20065438+0] No.37). It is agreed that Hunan Ningxiang Pharmaceutical Factory will be renamed as Hunan Huari Pharmaceutical Co., Ltd. And on July 3 of the same year, the drug approval number of Hunan Ningxiang Pharmaceutical Factory belongs to Hunan Huari Pharmaceutical Co., Ltd. ..

Hunan Huari Pharmaceutical Co., Ltd. is a subsidiary with independent legal personality controlled by Hunan Hai Yin Petrochemical Co., Ltd., located atNo. Jinting Road 16, Ningxiang County, Hunan Province. The factory is affiliated to Hunan Hai Yin Petrochemical Group, covering an area of 26,000 square meters. The power supply is provided by the 35KV substation of Hai Yin Group, including two 20t boilers, two10t boilers, Weishuihe pump station and two air compressors (6m3/min). The area has convenient transportation, complete production conditions and elegant environment. The company produces citric acid series raw materials and solid preparation products. Its production scale is 400 tons of citric acid, 100 tons of sodium citrate and 100 tons of potassium citrate. Citric acid series raw materials have a long history. Citric acid was registered in 78, and sodium citrate was registered in 89, and obtained the national patent. Potassium citrate was registered in 1994 and won the provincial excellent new product. In 2002, all of them were promoted to the approval number of National Medicine Zhunzi. The company has a total of employees 168, engaged in production 140, 28 managers and 43 production technicians, including 4 with bachelor's degree, 4 with junior college degree1person, 4 with technical secondary school degree1person, and 2 with long-term production experience, registered.

In 2002, the company invested 30 million yuan to transform the GMP workshop of solid preparations. The production capacity reaches 10000000 capsules, 6000000 packets of granules and 30000000 tablets.

July, 2004:16-July, 2004: 18, hunan food and drug administration conducted GMP on-site certification. On August 3, 2004, 65438+ passed the GMP certification of raw materials (citric acid, sodium citrate and potassium citrate) (Xiang F0055), which is the first GMP certification of citric acid series in China.

Hunan Huari Pharmaceutical Co., Ltd. now covers an area of 12000 square meters, with a building area of 4880 square meters, a production building area of 373 square meters, a storage area of 650 square meters, a quality inspection room area of 300 square meters, an administrative office area of 150 square meters and an auxiliary room area of 50 square meters. Subordinate boutique workshop (5000 tons/year), sodium citrate workshop (500 tons/year), potassium citrate workshop (150 tons/month), tablet workshop and vaseline workshop. At present, 15 are approved, including normal production 1 1 and fixed assets of 850,000 yuan. Mainly produces citric acid, sodium citrate, potassium citrate, calcium citrate, antibiotics, vitamins, anti-inflammatory hormones, tablets, capsules, granules, disinfection and sterilization ointment, dermatological preparations, yellow and white vaseline and other raw materials. The company has 50 employees, including graduate students 1 person, 2 licensed pharmacists, undergraduates 10, and colleges 19.

In August 2007, the company moved to a new address (East Second Ring Road, Ningxiang Economic Development Zone). After the overall relocation, the organization is perfect, all rules and regulations are complete, the operation process is clear, and the product production process is strictly controlled, which meets the requirements of drug GMP certification. From February 25 to February 26, 2007, hunan food and drug administration conducted GMP on-site certification. And passed the raw material medicine (anhydrous citric acid

Hunan Huari Pharmaceutical Co., Ltd. is a subsidiary of Hunan Changsha Shenghai Group, with independent legal personality. The company is located in the second ring road of Ningxiang County Economic Development Zone in Changsha. The factory is in Shenghai Group. The company has a registered capital of 5 million yuan, covering an area of 654.38+10,000 square meters, a workshop building area of 3,700 square meters, a laboratory area of 500 square meters and a clean room area of 240 square meters. The transportation in this area is convenient and the production supporting conditions are perfect.

The company has 70 employees, including 20 technicians, 7 managers, 8 inspection analysts and 3 quality control personnel. Production and quality management personnel are highly specialized. Main production equipment: dissolving tank, coarse filter, fine filter, concentrated crystallization tank, centrifuge, dryer, vibrating screen, purified water system, etc. Main analytical instruments: infrared spectrophotometer, ultraviolet spectrophotometer, moisture analyzer, muffle furnace, oven, clean workbench, analytical balance, electronic balance, PH meter, photometer, conductivity meter, acidity meter, polarimeter, etc.

On April 9, 2007, he obtained the certificate of anhydrous citric acid (National Medicine Zhunzi H200700 12).

On March/0/0, 2009, the registration documents of sorbic acid (Hunan Food and Drug Administration auxiliary word F200900 15) and sodium benzoate (Hunan Food and Drug Administration auxiliary word F200900 14) were obtained.

On September 6, 2009, the registration approval of sodium cyclamate was obtained (Hunan Food and Drug Administration auxiliary approval word F20090046).

On September 7th, 2009, we obtained stearic acid (Hunan Food and Drug Administration auxiliary standard word F20090045), magnesium stearate (Hunan Food and Drug Administration auxiliary standard word F20090044) and registration approval.

On June 28th, 2009, 10/0 obtained the registration approval document of sodium acetate (Hunan Food and Drug Administration Auxiliary Zhunzi F20090049).

On June 4th, 2009, we obtained the registration approval documents of anhydrous sodium sulfite (Hunan Edible Medicine Auxiliary Label F20090050), disodium EDTA (Hunan Edible Medicine Auxiliary Label F2009005 1) and potassium sorbate (Hunan Edible Medicine Auxiliary Label F20090052).

On June 6, 2009165438+1October 6, 2009, the board of directors of Shenghai Group Company decided to designate another refining workshop under the group company to produce citric acid series products as Hunan Huari Pharmaceutical Co., Ltd., as the second raw material production line, which simultaneously produces six kinds of raw materials, including citric acid, sodium citrate, potassium citrate, anhydrous citric acid, boric acid and borax.

On June 25, 2009, the registration approval documents of raw materials boric acid (national medicine standard word H2009411) and borax (national medicine standard word H20094 124) were obtained.

On February 25th, 20 10 passed the GMP certification of raw materials (anhydrous citric acid, citric acid, potassium citrate, sodium citrate, boric acid and borax) again (Xiang L0345).

Hunan Huari Pharmaceutical Co., Ltd. belongs to the first workshop of raw material production (production of boric acid, borax, citric acid, sodium citrate, potassium citrate, anhydrous citric acid, sorbic acid and sodium benzoate), the second workshop of raw material production (production of boric acid, borax, citric acid, sodium citrate, anhydrous citric acid) and the first workshop of pharmaceutical auxiliary materials production (production of potassium sorbate, sodium acetate, disodium EDTA, anhydrous sodium sulfite and honey). It is expected that new products will be launched at the end of 20 1 1. The distance between the second truck of API production and the first workshop of Huari Pharmaceutical Company is about 200 meters. The surrounding environment is well afforested and there is no bare land. All in the factory area of the group company. According to the requirements of Japan Dongmian Co., Ltd., it is a refining workshop specializing in the production of citric acid series products. Its production equipment meets the production process requirements of existing raw materials (boric acid, borax, citric acid, sodium citrate, potassium citrate and anhydrous citric acid) of Huari Pharmaceutical. The workshop covers an area of 324 square meters and is divided into six floors. 300,000-class clean area in the second workshop of raw material production, with a total area of 100 square meter, with independent air purification system. The clean area is mainly used for sub-packaging and internal packaging of products. Other processes are carried out in a closed equipment system from the beginning of fine filtration. The main large-scale equipment in this workshop 16 sets, all conveying pipes and equipment are made of stainless steel (3 16L), which meets the GMP production requirements.

At present, the capacity of the API workshop of Hunan Huari Pharmaceutical Co., Ltd. is 3,500 tons/year; The production capacity of pharmaceutical excipients is 400 tons/year. The company wholeheartedly provides our customers with high-quality products and good after-sales service.