What is the difference between COVID-19 vaccine and 123 injection? What is the difference between COVID-19 vaccine and 123 injection?

1 Shao, a researcher at China CDC, introduced at the press conference of the newly established joint prevention and control mechanism on 3/kloc-0 that there are three kinds of COVID-19 vaccines currently used in China: inactivated vaccine, adenovirus vector vaccine and recombinant protein vaccine. Vaccines with different technical routes have different characteristics in vaccine composition, production technology, immune mechanism and immune procedure.

2. The inactivated vaccine in China is to amplify novel coronavirus in cell culture, then inactivate and verify it, and finally purify and extract it. The composition and structure of this kind of vaccine are closest to natural virus (including all virus antigens), and it can produce a broader spectrum of immune response. The vaccine production process is mature, the quality is stable, and the side effects are few. The vaccine is stored at 2-8 degrees, which is convenient for transportation and use. The vaccine was inoculated with two injections. The first needle stimulates the immune system to produce memory cells, and the second needle induces a stronger antiviral immune memory response.

3. China's adenovirus vector vaccine is made by introducing novel coronavirus's S protein into adenovirus vector type 5, harvesting recombinant virus after culture and amplification, and then purifying it. Because the virus vector can infect cells efficiently and has strong immunogenicity, it is convenient and fast to use one-shot vaccination for some special emergency people, and it is also helpful to improve the vaccination rate in areas where it is difficult to complete multi-shot vaccination.

4. China's recombinant protein vaccine is to construct engineering cells expressing virus S protein or its receptor binding epitope by genetic engineering technology, culture a large number of cells and extract purified protein to make vaccine. The vaccine contains few virus components and high purity, and is generally immunized with three needles.

5. Shao said that the vaccines of the three technical routes are safe and effective, and the quality is controllable. One needle, two needles or three needles are the results of strict phase I, II and III clinical trials to determine the best immunization program of their respective vaccines. As all these vaccines meet the national and international standards of China COVID-19 vaccine, the public can use them with confidence. Because of the different composition and immunization program of each vaccine, the vaccinators have different tolerance to the side effects of different vaccines because of their different constitutions. They can choose vaccination according to their own needs and tolerance, and avoid and reduce the side effects of the vaccine under the guidance of doctors. One-dose, two-dose and three-dose COVID-19 vaccine currently used in China is the best immunization program according to the technical characteristics and clinical trial results of each vaccine.

6. The public only need to complete the vaccination of all kinds of vaccines according to the instructions, and don't give up halfway, so as to achieve the set vaccine protection effect, that is, to achieve the primary, secondary and tertiary prevention of infection, onset and spread to others in COVID-19.