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What is the biggest difficulty for human beings to move to Mars?

There are many issues to consider when immigrating to Mars.

The first is science and technology: round-trip time, the safety of Mars residential base, and the most important thing is the transformation of Mars environment-how to transform a stable and balanced ecological cycle system on Mars.

Secondly, it is comprehensive: the form of government after immigration, the social structure after immigration, the mentality of immigrants and non-immigrants, and the distribution of Mars resources in various countries.