Detection significance of glycosylated hemoglobin instrument

Diabetes mellitus is a group of endocrine and metabolic diseases, and its etiology and pathogenesis are not fully understood. At present, the work of detecting patients' blood sugar has been widely carried out in clinic. However, blood glucose measurement can only represent the immediate blood glucose level, suggesting the patient's physical condition at that time, and cannot be used as an index to evaluate the degree of disease control. Therefore, the glycosylated hemoglobin level reflects the average blood glucose level before the test 120 days, and has nothing to do with the blood drawing time, whether the patient is on an empty stomach, whether insulin is used, etc. It is a good index to judge the long-term control of diabetes. Glycosylated hemoglobin meter is an instrument used to detect the content of glycosylated hemoglobin. It is widely used:

First, the diagnosis of diabetes: the HbA 1c of healthy people is 4.0%-7.7%, and the HbA 1c of uncontrolled DM patients can be as high as10%-20%; Random detection of HbA 1c, if 9%, the standard, sensitivity and specificity of predicting diabetes are about 78%, 68% and 94% respectively. HBA 1c & gt； 10%, indicating that more than 80% are diabetic, with sensitivity of 43%, specificity of 99% and effective rate of 86%. Therefore, it is not recommended to diagnose diabetes with HbA 1c alone at present, because the accuracy is low.

Secondly, the determination of HbA 1c: it can help to judge the prognosis of diabetic patients with retinopathy, and its HbA 1c is 8%- 10%, indicating that the lesion is moderate and can be treated by laser; If it is greater than 10%, it is a serious lesion with poor prognosis. For gestational diabetes mellitus, it is more meaningful to judge whether it is teratogenesis, stillbirth and pre-eclampsia, so measuring HbA 1c is an important parameter to control gestational diabetes mellitus.

Third, it helps to understand the chronic complications of diabetes: blood glucose measurement only represents the immediate blood glucose level, prompting the patient's physical condition at that time, and cannot be used as an index to evaluate the degree of disease control.

Fourthly, it is the evaluation index of blood sugar control: as the evaluation index of long-term blood sugar control of diabetic patients; The measurement of glycosylated hemoglobin (HbA 1c) aims to eliminate the influence of blood sugar fluctuation on the observation of disease control, so it is a valuable blood sugar control index for patients with type I diabetes with large blood sugar fluctuation. For patients with type 2 diabetes, it can be used as an auxiliary examination to determine whether oral drugs are ineffective and whether insulin therapy is needed.