? 20 19 licensed pharmacists' knowledge of traditional Chinese medicine-high-frequency examination questions 7

20 19 licensed pharmacists' knowledge of traditional Chinese medicine-high-frequency examination questions 7

Best multiple choice questions

1, and the melting time of fat matrix suppository is

A, 15 minutes

B, 30 minutes

45 minutes

D, 60 minutes

E, 75 minutes

2. The route of drug absorption after suppository is administered at 2 cm of anus.

First, drugs → inferior rectal vein and anal vein → inferior vena cava → great circulation

B, drugs → superior rectal vein → portal vein → great circulation

C, drugs → portal vein → liver → great circulation

D, drugs → inferior rectal vein and anal vein → liver → great circulation

E, drugs → inferior rectal vein and anal vein → most drugs enter inferior vena cava → great circulation.

3. The best place to give full play to the systemic effect of suppository is rectum.

A, should be 2cm from the anus.

B, close to the superior, middle and inferior rectal veins

C, near the superior rectal vein

D, near the inferior rectal vein

E, close to the anal sphincter

4. The purpose of adding glycerol to hard capsule shell is

A, increase the gel strength of the glue solution

B, to prevent the oxidation of drugs

C, prevent mildew.

D, increase the toughness and elasticity of the capsule.

E, adjust the taste of the capsule.

5. When preparing empty capsules, it is necessary to add auxiliary materials to ensure the quality of capsule shell, and its agar is used as.

First, preservatives

B, sunscreen

C, thickener

D, plasticizer

E, molding materials

6, can be used as soft capsule filling material is

First, the aqueous solution of drugs

B, ethanol solution of drugs

C, aqueous suspension of drugs

D, oil-water solution of drugs

E. oil-in-water solution of drugs

7, hard capsule shell don't need to add is

I. Disintegrator

Thickener

C, sunscreen

D, colorant

E, preservatives

8. The current edition of Pharmacopoeia stipulates that the moisture limit of hard capsule contents is

a、≤5.0%

b、≤6.0%

c、≤9.0%

d、≤ 10.0%

e、≤ 12.0%

9. The current Pharmacopoeia stipulates that the disintegration time limit of hard capsules is as follows

A, 15 minutes

B, 20 minutes

Thirty minutes

D, 35 minutes

E, 40 minutes

10, the improper description of the characteristics of water polo is

A, smooth surface, not easy to absorb moisture deterioration

B, convenient to take and store.

C, drug uniformity and dissolution time are not easy to control.

D, improper operation is easy to affect dissolution and disintegration.

E, slow dissolution and drug release can reduce adverse reactions.

1 1. Drugs with strong toxicity and irritation should be made.

First, water pills

B, honey pills

C, wax pills

D, concentrated pills

E, honey pills

12, and the dissolution time of dropping pills is

One or five minutes.

15 minutes

Thirty minutes

D, 45 minutes

E, 60 minutes

13, the following do not need to do dissolution time limit test is

First, small honey pills

B, big honey pill

C, water pills

D, concentrated pills

E. dropping pills

14, unless otherwise stipulated in China Pharmacopoeia, the moisture limit of honey pills is

a、≤ 15%

b、≤ 16%

c、≤ 17%

d、≤ 18%

e、≤ 1g%

15, the current pharmacopoeia stipulates that the moisture content limit of granules is

Answer: ≤6.0%

b、≤5.0%

c、≤8.0%

d、≤4.0%

E, there is no regulation

16, the characteristics of particles do not include

First, the dosage is small

B, the preparation process is suitable for large-scale production.

C, quick absorption, quick effect

D, easy to carry and carry

Large surface area and unstable quality.

In the particle size inspection specified in 17 and China Pharmacopoeia 20 10, the sum of particles and powder that cannot pass through 1 and can pass through No.5 sieve shall not pass.

a、 10%

b、 12%

c、5%

d、6%

e、 15%

18, all the decoction pieces in the prescription are crushed into fine powder, and the traditional Chinese medicine tablets made by adding appropriate excipients are called

I. Semi-extract tablets

B, purifying tablets

C, dispersible tablets

D, whole extract tablet

E, full powder tablets

19, and tablet excipients that can be used as disintegrants are as follows

First, talcum powder

dextrin

ethylcellulose

D. Arabic gum

Sodium carboxymethyl starch

20. At present, the mixed excipients for tablet preparations instead of lactose are as follows

1. Starch, dextrin and mannitol (5: 1: 1)

B, starch, dextrin and powdered sugar (5: 1: 1)

C, starch, powdered sugar and dextrin (7: 2: 1)

D, starch, dextrin and powdered sugar (7: 5: 1)

E, starch, dextrin and powdered sugar (7: 1: 1)

2 1. It can be used as a binder, disintegrant, glidant and diluent for tablets. The excipients that can be used for direct compression of powder are as follows.

First, starch slurry

B, microcrystalline cellulose

C, syrup

ethanol

hydroxypropyl methylcellulose

22. Excellent glidants, lubricants, anti-sticking agents and absorbent accessories for powder direct compression are as follows.

I. Sodium dodecyl sulfate

polyethyleneglycol

C. magnesium stearate

D, talcum powder

E, micro-powder silica gel

23. The following substances can be used as fillers, disintegrants and absorbents.

First, microcrystalline cellulose

B, sodium carboxymethyl cellulose

C, starch

dextrin

E, micro-powder silica gel

24. Sodium carboxymethyl starch is used as a disintegrant of tablets, and its mechanism of action is mainly as follows.

First, expansion

capillarity

C, wetting effect

D, gas production

E, enzymolysis

25, the following can be used as tablet disintegrants are

A. calcium hydrogen phosphate

B, drying the starch

C, talcum powder

dextrin

glucose

26. Magnesium stearate can be used as a tablet preparation.

First, wetting agent

B, lubricant

C, absorbent

D, diluent

E, drying the adhesive.

27, suitable as solution tablets and effervescent tablets lubricant is

I. Sodium carboxymethyl starch

B, talcum powder

mannitol

polyethyleneglycol

E. magnesium stearate

28, the time limit for vaginal melting is

One or five minutes.

15 minutes

Thirty minutes

D, 45 minutes

E, 60 minutes

29. The description of the latest edition of China Pharmacopoeia on the inspection of tablet weight difference is correct.

A, there shall be no 2 tablets exceeding the limit 1 times.

B, 1 tablet shall not exceed 2 times the limit.

C, beyond the weight difference limit shall not exceed 3 pieces.

D, beyond the weight difference limit shall not exceed 2 pieces.

E, still need to check after icing.

30, "China Pharmacopoeia" 20 10 version of a regulation, the disintegration time of traditional Chinese medicine tablets, the right is

A, 60min endogenous medicinal powder tablets.

B, extract the tablets within 30 minutes.

C, 30min containing tablets.

D, semi-extract tablets within 30 minutes.

E, sugar-coated tablets within 60min minutes.

3 1, two-phase aerosol is

I. Solution aerosol

B, O/W emulsified aerosol

C, W/O emulsified aerosol

D, suspended aerosol

E, inhalation of powder mist agent

32, foam spray dosage form is

I. Suspended aerosol

B, inhalation of powder mist agent

C, solution aerosol

D, foaming agent

E, spraying

33. The main absorption site of inhaled aerosol drugs is

First, alveoli

B, trachea

C, bronchus

D, bronchioles

E. throat

34, about the narrative of propellant, wrong for

1. Propellant is a substance with high boiling point.

B, the vapor pressure of propellant at room temperature is greater than atmospheric pressure.

C, the propellant generates pressure in the pressure-resistant container.

D, propellant is the solvent of drugs in aerosol.

E, propellant is the diluent of drugs in aerosol.

35. The factors that determine the dosage of aerosol each time are as follows

First, the dosage of drugs

B, the amount of rhyme

C, the amount of propellant

D, the volume of pressure vessel

E, quantitative valve volume

36. The following statement about the concept of aerosol is correct.

First, it refers to the preparation of drugs and suitable propellants in a pressure-resistant container with a special valve system.

B. It is a preparation that sprays the liquid medicine into mist with the help of the pressure of a manual pump.

C, refers to the micronized drugs and carriers in the form of capsules, vesicles or large-dose storage, and patients actively inhale atomized drug preparations by using special dry powder inhalation devices.

D refers to preparations made of micronized drugs and carriers in the form of capsules and vesicles in pressure-resistant sealed containers with special valve systems.

E, refers to drugs and suitable propellants. A special dry powder inhalation device is used, and atomized drugs are prepared by patients' active inhalation.

37, aerosol quality requirements, the particle size of most inhaled aerosol and spray powder should be controlled in

A, 3μm or less

B, 5μm or less

6μm or less

8μm or less in diameter

E, lower than12 μ m.

38, can increase the transparency and hardness of adhesive, and have a corrective effect of accessories are

First, liquor

B. alum

C, sesame oil

D, rock sugar

E. yellow rice wine

39. When making glue, the purpose of adding rock sugar is

Increase transparency and hardness

Reduce the viscosity of rubber block

C, defoaming when collecting glue

D, removing impurities

The right taste and smell

40, boiled donkey-hide gelatin raw materials are

A, high quality class a

B, high-quality bones

C, high quality cowhide

D, high-quality donkey skin

E, high-quality speakers

Answer part

1、

Correct answer b

Unless otherwise specified, suppositories containing fat matrix should be completely melted, softened or pressed without hard core within 30 minutes; Suppositories containing water-soluble matrix should be completely dissolved within 60 minutes.

2、

Correct answer e

After anal administration, the main ways of drug absorption in rectum are as follows: ① absorption through superior rectal vein, entry into liver from portal vein, and then entry into large circulation from liver; ② Absorbed through the inferior rectal vein and anal vein, bypassed the liver through the internal iliac vein, and directly entered the great circulation through the inferior vena cava; ③ Absorbed by rectal lymphatic system.

3、

Correct answer a

The depth of suppository inserted into rectum affects the absorption of drugs. When the suppository is inserted 2 cm away from the anal orifice, 50% ~ 70% of its dose cannot pass through the portal vein system. In addition, the presence of feces in the rectum, diarrhea and tissue dehydration will all affect the absorption of drugs from the rectum. The pH value of rectal fluid is about 7.4, and it has no buffering capacity, which affects the absorption of weak acid and weak base drugs.

4、

Correct answer d

Plasticizers, such as glycerol, sorbitol and sodium carboxymethyl cellulose, can increase the toughness and plasticity of capsule shell.

5、

Correct answer c

Thickener: agar can increase the coagulation force of glue.

6、

Correct answer d

Analysis on the requirements of soft capsules for filling materials: Soft capsules can be filled with various oils or drug solutions or suspensions that have no dissolution effect on the capsule wall, and can also be filled with solid drugs.

7、

Correct answer a

Additives needed for hard capsules are: plasticizer, thickener, opacifier, colorant, preservative, brightening agent and aromatic flavoring agent.

8、

Correct answer c

Moisture content: Unless otherwise specified, the moisture content of hard capsules shall not exceed 9.0%. When hard capsules are liquid or semi-solid, the moisture content shall not be checked.

9、

Correct answer c

Disintegration time: 30 minutes for hard capsules and 1 hour for soft capsules.

10、

Correct answer e

The characteristics of water pills are: ① the pills are small, smooth in surface, convenient to take, difficult to absorb moisture and easy to store; (2) Pills can be made by layers according to the nature of drugs. Volatile and irritating drugs can flood into the inner layer to cover up the bad smell of drugs and improve the stability of volatile components; Or that slow-release and quick-release drug are respectively diffused into the inn layer and the outer layer of the pill to prepare a long-acting preparation; (3) easy to dissolve and disperse, fast in absorption and effect, and especially suitable for relieving exterior syndrome and promoting digestion; ④ The production equipment is simple, and it can be prepared in small batch or produced in large batch. ⑤ Most pieces are fine powder, which is easy to cause microbial contamination; The uniformity and dissolution time of drugs are also difficult to control.

1 1、

Correct answer c

Wax pill refers to the pill made of fine powder of decoction pieces with beeswax as adhesive. "Wax pill is difficult to take, but it takes effect or does not hurt the spleen and stomach when it is taken by rotation", that is, wax pill is insoluble in the body and slowly releases drugs for a long time, which is similar to the modern bone sustained-release and controlled-release drug system. Drugs with strong toxicity or irritation can be made into wax pills to reduce toxicity and irritation. However, the drug release rate is difficult to control, and there are few varieties of wax pills at present.

12、

Correct answer c

Time limit for dissolution: Unless otherwise specified, Xiaomi Pill, Shuimi Pill and Shuiwan should be dissolved within 65438±0h; Concentrated pills and paste pills should be completely dissolved within 2 hours; Dropping pills should be completely dissolved within 30 minutes, and coated dropping pills should be completely dissolved within 65438±0h hours. If the wax pill is inspected in hydrochloric acid solution (9→ 1000) for 2h, it shall not be broken, disintegrated or softened, and then it shall be completely disintegrated in 1h when it is inspected in phosphate buffer solution (pH6.8). Do not check the dissolution time limit of big honey pills.

13、

Correct answer b

Unless otherwise specified, the dissolution time limit of honey pills and pills taken after grinding, chewing or dispersing with boiling water and yellow wine. Not necessary.

14、

Correct answer a

Unless otherwise specified, the moisture content of honeyed pills and concentrated honeyed pills shall not exceed15.0%; Honeyed pills and concentrated honeyed pills shall not exceed12.0%; Water pills, ointment pills and concentrated water pills shall not exceed 9.0%. Wax pills and dropping pills do not check moisture.

15、

Correct answer c

Water content: Unless otherwise specified, the water content of particles shall not exceed 8.0%.

16、

Correct answer e

The characteristics of the granules are: ① small dosage, convenient to take, carry, store and transport; ② Good color, smell and taste, which is welcomed by patients; (3) The enteric-coated granules are acid-resistant, and releasing active ingredients in intestinal juice or controlling the local release of drugs in the intestine can prevent the drugs from decomposing in the stomach and avoid irritation to the stomach; (4) it can be made into sustained and controlled release preparation to achieve the purpose of sustained and controlled release; ⑤ Suitable for industrial production and stable product quality; ⑥ When necessary, coating can increase moisture resistance and cover up the bad smell of drugs; ⑦ Some traditional Chinese medicine granules have certain hygroscopicity, which is easy to absorb moisture and agglomerate due to lax packaging; A few varieties have loose particles and fine powder.

17、

Correct answer e

Resolution granularity of the answer: the sum of those that can't pass through 1 and those that can pass through No.5 sieve does not exceed 15%.

18、

Correct answer e

This question examines the types of traditional Chinese medicine tablets. The types of tablets mainly include: ① whole extract tablets: tablets made of extracts extracted from all decoction pieces of the prescription; (2) Semi-extract tablet: a tablet made by mixing the fine powder of some decoction pieces of this prescription with thick paste made of other medicinal materials; (3) Full-powder tablet: a tablet made by pulverizing all the decoction pieces in the prescription into fine powder and adding a proper amount of auxiliary materials; ④ Purified tablets: tablets made of active ingredients extracted from prescription pieces or fine powder of active parts as raw materials, and added with appropriate auxiliary materials.

19、

Correct answer e

Extension of answer analysis

After absorbing water, the disintegrant in tablets obviously increases in volume due to full expansion, which promotes the disintegration and disintegration of tablet binding force. The swelling capacity of disintegrant can be evaluated by its swelling rate, and the greater the swelling rate, the better the disintegration effect. The swelling rate of carboxymethyl starch sodium after water absorption is 300 times of the original volume, and the disintegration effect is very obvious. Some drugs expand the residual air in tablets due to the heat generated during dissolution, which also promotes the disintegration of tablets to some extent.

20、

Correct answer e

Answer analysis lactose

White crystalline powder, slightly sweet; Soluble in water, does not absorb moisture; Good fluidity and compressibility; It has stable properties and can be compatible with most drugs. Lactose is an excellent filler. Tablets made of lactose are smooth, beautiful, suitable in hardness, rapid in drug release, which does not affect the content determination of the main drug, and does not prolong the disintegration time of the tablets after long-term storage, especially suitable for hygroscopic drugs. Spray-dried lactose can be used as an auxiliary material for direct powder compression. However, the quantity of this product is small and the price is high. At present, the mixture of starch, dextrin and powdered sugar (7: 1: 1) is widely used in China.

2 1、

Correct answer b

Microcrystalline cellulose can be used as binder, disintegrant, glidant and diluent for tablets, and can be used for direct compression of powder. Because of its hygroscopicity and deliquescence, it is not suitable for coated tablets and some drugs that are unstable in water.

22、

Correct answer e

Micro-powder silica gel: pale white amorphous powder, insoluble in water, but hydrophilic; Large specific surface area, good fluidity, compressibility and adhesion. It is an excellent glidant, lubricant, anti-sticking agent and absorbent for direct compression of powder.

23、

Correct answer c

Answer analysis starch

Glucose-based polymer, a white fine powder composed of amylose (glucose unit linked only by α- 1 4 glycosidic bond) and amylopectin (amylopectin polymerized by D- glucose linked by α- 1 6 glycosidic bond); Stable in nature and compatible with most drugs; Insoluble in cold water and ethanol, it can be gelatinized when heated to 62 ~ 72℃ in water; Swelling in water, but gradually hydrolyzing in wet state, heating in acid or alkali, losing its swelling effect; Generally, it contains 12% ~ 15% moisture and is not deliquescent. This product is cheap and easily available, and it is the most commonly used diluent, absorbent and disintegrant for tablets. There are many kinds of starch, among which corn starch is the most commonly used, and potato starch can also be used.

24、

Correct answer a

Swelling: After absorbing water, the disintegrant in the tablet is fully expanded, and its volume is significantly increased, which promotes the disintegration and disintegration of the tablet's binding force. The swelling capacity of disintegrant can be evaluated by its swelling rate, and the greater the swelling rate, the better the disintegration effect. The swelling rate of carboxymethyl starch sodium after water absorption is 300 times of the original volume, and the disintegration effect is very obvious.

25、

Correct answer b

Dry starch is the most commonly used traditional disintegrant, which is a mixture of glucose polymers composed of about 20% amylose and 80% amylopectin.

26、

Correct answer b

Magnesium stearate: white fine powder. Strong lubricity, good adhesion, but poor flow aid; It is hydrophobic, and the large dosage will affect the disintegration or fragmentation of tablets. The dosage is generally 0.3% ~ 1.0% of dry granules.

27、

Correct answer d

Polyethylene glycol: PEG4000 or PEG6000 is often used as a water-soluble lubricant, suitable for solution tablets or effervescent tablets, and the dosage is 1% ~ 4%.

28、

Correct answer c

Vaginal films should be checked for melting time limit. Unless otherwise specified, all three kinds of vaginal tablets should be dissolved or disintegrated within 30 minutes, and pass through a porous metal disk, or only a small amount of soft pieces without hard cores remain.

29、

Correct answer d

The weight of each tablet is compared with the average tablet weight or the marked tablet weight, no more than 2 tablets exceed the weight difference limit, and no 1 tablet exceeds the limit 1 times. The core of sugar-coated tablets should be checked for weight difference and conform to the regulations, and the weight difference should not be checked after sugar-coating. After coating, check the weight difference of coated parts and conform to the regulations.

30、

Correct answer e

Unless otherwise specified, all 6 test pieces shall disintegrate within 65438 05 minutes; 6 tablets of raw powder should be completely disintegrated within 30 minutes; Extract (semi-extract) tablets and sugar-coated tablets should all disintegrate within 1 hour. When the film-coated tablets are examined in hydrochloric acid solution (9→ 1000), they should all disintegrate within 30 minutes; Chinese medicine tablets should disintegrate completely within 1 hour. All buccal tablets should disintegrate or dissolve within 10 minutes. All sublingual tablets should disintegrate and dissolve within 5 minutes. All soluble tablets should disintegrate and dissolve within 3 minutes. Orally disintegrating tablets should disintegrate completely within 60 seconds and pass through a sieve with an inner diameter of 765438 00μ m. Enteric disintegrating tablets should be inspected in hydrochloric acid solution (9→ 1000) for 2 hours, and each tablet should not be cracked, disintegrated or softened, and then inspected in phosphate buffer (pH6.8), and should disintegrate completely within 1 hour. Colon-specific enteric-coated tablets should be tested according to the regulations under each variety. Each tablet shall not crack, disintegrate or deform in hydrochloric acid solution (9→ 1000) and phosphate buffer solution below pH6.8, and completely disintegrate in phosphate buffer solution with pH 7.5 ~ 8.0 1 hour. Effervescent tablets are placed in a beaker containing 200ml of water (the water temperature is 20℃ 5℃), and many bubbles are released. When the gas around the tablets or fragments stops escaping, the tablets should be dissolved or dispersed in water, leaving no aggregated particles. Unless otherwise specified, each tablet should disintegrate within 5 minutes.

3 1、

Correct answer a

Aerosol can be divided into two-phase aerosol (gas phase and liquid phase) and three-phase aerosol (gas phase, liquid phase, solid phase or liquid phase) according to prescription composition. Solution aerosol belongs to two-phase aerosol, emulsion aerosol and suspended aerosol belong to three-phase aerosol.

32、

Correct answer d

Aerosol refers to the preparation that raw materials or raw materials and additives are sealed together with a suitable propellant in a pressure-resistant container with a special valve system. When in use, the contents are sprayed in mist by the pressure of the propellant for inhalation in the lungs or directly sprayed on the mucous membrane and skin of the cavity. When the aerosol content is foamed or semi-solid after being sprayed, it is called foaming agent or gel/cream.

33、

Correct answer a

When inhaling aerosol or spray, the drug can directly act on bronchial smooth muscle when inhaled in mist, and the droplets with appropriate size are evenly distributed and deposited in alveoli, which is the main absorption site of the drug.

34、

Correct answer a

Propellant: It is a suitable liquid gas with low boiling point, and its vapor pressure is higher than atmospheric pressure at normal temperature. When the valve is opened, the propellant is rapidly gasified to generate pressure, which overcomes the attraction between liquid molecules and disperses the drug into atomized particles for ejection. Therefore, propellant is the driving force for injecting drugs, and sometimes it is also used as a solvent and diluent for drugs.

35、

Correct answer e

Quantitative valve: In addition to the components of general valves, there are quantitative chambers or cups made of plastic or metal, and their volume determines the dosage of each drug.

36、

Correct answer a

Aerosol refers to the preparation that raw materials or raw materials and additives are sealed together with a suitable propellant in a pressure-resistant container with a special valve system. When in use, the contents are sprayed in mist by the pressure of the propellant for inhalation in the lungs or directly sprayed on the mucous membrane and skin of the cavity.

37、

Correct answer b

The particle size of aerosol and spray for inhalation should be controlled below 65438 00 5μ m, and most of them should be below 5 μ m. ..

38、

Correct answer d

Crystal sugar: white, clean and impurity-free is preferred. Rock sugar can increase the transparency and hardness of the adhesive and has a corrective effect. You can also use sugar instead.

39、

Correct answer a

Crystal sugar: white, clean and impurity-free is preferred. Rock sugar can increase the transparency and hardness of the adhesive and has a corrective effect. You can also use sugar instead.

40、

Correct answer d

Donkey skin is the raw material for boiling Ejiao, especially Zhang Damao Black, which is thick and disease-free.